Repair Versus Non-repair of the Aortic Arch in Type A Aortic Dissection

Enrolling by invitationOBSERVATIONAL
Enrollment

900

Participants

Timeline

Start Date

January 1, 2014

Primary Completion Date

June 30, 2025

Study Completion Date

December 30, 2025

Conditions
Aortic DissectionAortic ArchAortic Dissection RuptureAortic Dilatation
Interventions
PROCEDURE

Conservative TAAD-R

Cardiac arrest will be ensured using antegrade potassium-rich cardioplegia solution delivered directly into the coronary ostium or after coronary sinus cannula insertion, in patients with aortic regurgitation aorta will be resected down to the sinotubular junction and the thrombus located in the false lumen of the aortic root will be removed so that the aortic lesion could be visualized. The commissures will be resuspended using 4-0 or 5-0 sutures reinforced with a Teflon pledget over each commissure. A 4-0 or 5-0 polypropylene suture will be chosen to seal the proximal anastomosis and this suture line will also be used to secure the intima to the adventitia. In patients revealing normal-sized aortic roots associated with poor-quality valve leaflets, concomitant aortic valve replacement with conventional xenograft or mechanical prosthesis will be preferred.

PROCEDURE

Extensive TAAD- R

Patients who experienced dilatation of the sinuses of Valsalva \>4.5 cm in diameter on computed tomography imaging, those with connective tissue disease, or those in whom intimal tears extended into the sinuses, will undergoing replacement of the aortic root using a biologic or mechanical composite valve graft or valve-sparing root reimplantation procedure.Total arch replacement procedures (TARP) will fulfilled with the use of deep hypothermic circulatory arrest and with either antegrade or retrograde cerebral perfusion, maintaining systemic cooling between 19°C to 25°C and depending on the surgeon's practice.TARPs will be carried out using 1- and 4-branch grafts and involved the resection of all the aortic tissue up to the left common carotid artery (total arch)

Trial Locations (1)

93200

Francesco Nappi, Saint-Denis

All Listed Sponsors
collaborator

Henri Mondor University Hospital

OTHER

collaborator

Universita degli Studi di Genova

OTHER

collaborator

Pitié-Salpêtrière Hospital

OTHER

lead

Centre Cardiologique du Nord

OTHER