Disitamab Vedotin Combined With Radiotherapy for Bladder Preservation

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 1, 2023

Primary Completion Date

July 1, 2025

Study Completion Date

July 1, 2026

Conditions
Urothelial Carcinoma
Interventions
DRUG

Disitamab Vedotin

Four cycles of neoadjuvant therapy with Vidiximab (2.0mg/kg) were administered first, followed by bladder sparing therapy using maximized TURBT combined with radiotherapy and chemotherapy. The patient will receive vidiximab combined with local radiotherapy after maximizing TURBT surgery. The subjects received treatment with Vidixitol every two weeks for six consecutive treatment cycles, and simultaneously received 1 month of radiation therapy (SBRT, total dose of bladder irradiation field greater than 50 Gy)

RADIATION

radiotherapy

radiotherapy

All Listed Sponsors
lead

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

NCT05912205 - Disitamab Vedotin Combined With Radiotherapy for Bladder Preservation | Biotech Hunter | Biotech Hunter