NCT05911178View on ClinicalTrials.gov

Impact of Microglial Activation on Synaptic Density in Alzheimer's Disease

NARecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

October 18, 2023

Primary Completion Date

February 17, 2028

Study Completion Date

April 17, 2028

Conditions
Alzheimer Disease
Interventions
RADIATION

[11C]-UCB-J

"PET tracer binding to SV2A protein, used to study synaptic vesicle density."

RADIATION

[18F]-DPA-714

"PET tracer binding to TSPO protein, used to study microglial activation."

RADIATION

[18F]-RO-948

"PET tracer binding to tau protein, used to study the topography of tau deposition."

RADIATION

[11C]-PiB

PET tracer binding to Aβ40 and Aβ42 fibrils and insoluble plaques containing the aforementioned Aß peptides, used to study the topography of amyloid deposition.

Trial Locations (3)

Unknown

NOT_YET_RECRUITING

CHU de Lille, Lille

RECRUITING

GHU Saint Anne Psychiatrie & Neurosciences, Paris

NOT_YET_RECRUITING

CHU de Rouen, Rouen

All Listed Sponsors
collaborator

Roche Pharma AG

INDUSTRY

lead

Centre Hospitalier St Anne

OTHER