A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

687

Participants

Timeline

Start Date

September 14, 2023

Primary Completion Date

September 1, 2026

Study Completion Date

September 1, 2026

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Atezolizumab

Atezolizumab will be administered by intravenous (IV) infusion at a fixed dose of 1200 milligrams (mg) on Day 1 of each 21-day cycle.

DRUG

Bevacizumab

Bevacizumab will be administered by IV infusion at a dose of 15 milligrams per kilogram (mg/kg) on Day 1 of each 21-day cycle.

DRUG

Tiragolumab

Tiragolumab will be administered by IV infusion at a fixed dose of 600 mg on Day 1 of each 21-day cycle.

OTHER

Placebo

Placebo matching tiragolumab will be administered by IV infusion on Day 1 of each 21-day cycle.

Trial Locations (172)

100

National Taiwan Uni Hospital, Taipei

333

Chang Gung Medical Foundation - Linkou, Taoyuan District

404

China Medical University Hospital, Taichung

710

Chi-Mei Medical Centre, Tainan City

1023

Auckland City Hospital, Auckland

1200

Cliniques Universitaires St-Luc, Brussels

2193

Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

2650

UZ Antwerpen, Edegem

6021

Wellington Hospital, Wellington

8011

Christchurch Hospital, Christchurch

8800

AZ Delta (Campus Rumbeke), Roeselare

10016

NYU Langone, New York

10029

Icahn School of Medicine at Mount Sinai, New York

10330

Chulalongkorn Hospital, Bangkok

10400

Ramathibodi Hospital, Bangkok

10408

National Cancer Center, Goyang-si

10461

Montefiore Medical Center, The Bronx

10468

James J Peters VA Hospital / Mental Illness Research Education and Clinic Center, The Bronx

13285

Fondation Hopital Saint Joseph, Marseille

13496

CHA Bundang Medical Center, Gyeonggi-do

14000

Instituto Nacional de Ciencias Médicas Y de Nutricion Salvador Zubirán, Mexico City

14033

CHU CAEN - Hôpital de la Côte de Nacre, Caen

16132

Az. Osp. Uni Ria San Martino, Genoa

19107

Thomas Jefferson Uni, Philadelphia

20010

MedStar Washington Hosp Center, Washington D.C.

20089

IRCCS Istituto Clinico Humanitas, Rozzano

21202

Mercy Medical Center, Baltimore

22030

Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi, Edirne

23007

Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico, Jaén

26953

Centre Hospitalier Valence, Valence

27514

University of North Carolina at Chapel Hill, Chapel Hill

28007

Hospital General Universitario Gregorio Marañon, Madrid

28027

Clinica Universitaria de Navarra de Madrid;Servicio de Hepatologia, Madrid

28040

Hospital Clinico San Carlos, Madrid

28222

Hospital Universitario Puerta de Hierro, Madrid

31008

Hospital de Navarra, Navarra

Clinica Universitaria de Navarra, Pamplona/iruña

33011

Hospital Universitario Central de Asturias, Oviedo

33125

Miami VA Healthcare System, Miami

33705

Florida Cancer Specialist, North Region, St. Petersburg

33901

Florida Cancer Specialists - Fort Myers (Broadway), Fort Myers

35575

?zmir Medical Point, Kar?iyaka

37134

A.O.U.I. Verona-Ospedale Policlinico G.B. Rossi Borgo Roma, Verona

39120

Universitätsklinikum Magdeburg Klinik für Gastroenterologie und Hepatologie, Magdeburg

40002

Khon Kaen Uni, Khon Kaen

40138

A.O. S. Orsola Malpighi, Bologna

40217

Norton Cancer Institute - Audubon, Louisville

44033

Ulsan University Hosiptal, Ulsan

44093

Hopital Hotel Dieu Et Hme, Nantes

46010

Hospital Clinico de Valencia, Valencia

48202

Henry Ford Health System, Detroit

49503

Cancer & Hematology Centers of Western Michigan, Grand Rapids

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

51092

Hopital Robert Debre, Reims

53792

Univ of Wisconsin-Madison, Madison

54511

Hopitaux de Brabois - Gastro-Entereologie, Vandœuvre-lès-Nancy

55125

Minnesota Oncology Hematology Woodbury, Woodbury

55131

Uniklinik Mainz, Mainz

55905

Mayo Clinic Rochester, Rochester

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59037

CHRU de Lille - Hopital Claude Huriez, Lille

60612

University of Illinois, Chicago

63110

Washington Uni School of Medicine, St Louis

68020

Centro de Investigacion Clinica de Oaxaca, Oaxaca City

70121

Ochsner Cancer Inst., New Orleans

71913

Genesis Cancer Center, Hot Springs

72076

Universität Tübingen, Tübingen

73730

Klinikum Esslingen, Esslingen am Neckar

75216

North Texas VA Medical Center, Dallas

75571

APHP - Hopital Saint Antoine, Paris

77005

Kelsey Seybold Clnic, Houston

87042

Hopital Dupuytren, Limoges

90033

University of Southern California, Los Angeles

90127

A.O.U. Policlinico Paolo Giaccone, Palermo

90404

UCLA Cancer Center, Santa Monica

91010

City of Hope Cancer Center, Duarte

92037

University of California San Diego Moores Cancer Center, La Jolla

93611

UCSF Fresno at Community Cancer Institute, Clovis

94304

Stanford Cancer Center, Palo Alto

Va Palo Alto Health Care System, Palo Alto

94804

Hopital Paul Brousse, Villejuif

98101

Virginia Mason Medical Center, Seattle

98104

Swedish Cancer Inst., Seattle

100142

Beijing Cancer Hospital, Beijing

110004

Shengjing Hospital of China Medical University, Shenyang

130021

The First Hospital of Jilin University, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

168583

National Cancer Centre, Singapore

200032

Zhongshan Hospital Fudan Unvierstiy, Shanghai

200127

Renji Hospital Shanghai Jiaotong University School of Medicine, Shanghai

230001

Anhui Provincial Hospital, Hefei

230601

The Second Affiliated Hospital of Anhui Medical University, Hefei

300060

Tianjin Cancer Hospital, Tianjin

310003

The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou

310014

Zhejiang Provincial People?s Hospital, Hangzhou

323000

Lishui Central Hospital, Lishui

350005

The First Affliated Hospital Of Fujian Medical University, Fuzhou

350025

Mengchao Hepatobiliary Hospital Of Fujian Medical University, Fuzhou

410007

Peoples Hospital of Hunan Province, Changsha

410013

Hunan Cancer Hospital, Changsha

430030

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

510515

Nanfang Hospital, Southern Medical University, Guangzhou

610047

West China Hospital - Sichuan University, Chengdu

710061

First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an

710119

Xi'an Inernational Medical Center Hospital, Xi'an

721008

Baoji Central Hospital, Baoji

930232

Jos University Teaching Hospital, Jos

06106

Hartford Healthcare Cancer Institute at Hartford Hospital, Hartford

10032-3725

Columbia University, New York

29055-450

CEDOES - Diagnóstico e Pesquisa, Vitória

30170-080

Oncoclínicas do Brasil - BELO HORIZONTE, Belo Horizonte

50040-000

Hospital do Cancer de Pernambuco - HCP, Recife

90020-090

Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90610-000

Hospital Sao Lucas - PUCRS, Porto Alegre

14784-400

Hospital de Cancer de Barretos, Barretos

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

22290-160

Clinicas Oncologicas Integradas - COI, Rio de Janeiro

L8V 1C3

Juravinski Hospital, Hamilton

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

H3T 1E2

Jewish General Hospital, Montreal

H4A 3J1

McGill University Health Centre - Glen Site, Montreal

Unknown

Sun yat-sen University Cancer Center, Guangzhou

Centre National d'Oncologie Médicale et de Radiothérapie Alassane Ouattara (CNRAO), Abidjan

Sweden Ghana Medical Center, Accra

Queen Mary Hospital, Hong Kong

Prince of Wales Hosp, Shatin

Az. Osp. G. Panico, Tricase

University of Nairobi - Institute of Tropical and Infectious Diseases, Nairobi

Lagos University Teaching Hospital Lagos (LUTH), Lagos State, Lagos

Uganda Cancer Institute, Kampala

BP 1463 Abidjan

Polyclinique Internationale Sainte Anne- Marie (PISAM), Abidjan

0000

KBTH, Accra

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome

470-1192

Fujita Health University Hospital, Aichi

260-8677

Chiba University Hospital, Chiba

277-8577

National Cancer Center Hospital East, Chiba

790-0024

Ehime Prefectural Central Hospital, Ehime

830-0011

Kurume University Hospital, Fukuoka

734-8551

Hiroshima University Hospital, Hiroshima

060-0033

Sapporo Kosei General Hospital, Hokkaido

060-8648

Hokkaido University Hospital, Hokkaido

920-8641

Kanazawa University Hospital, Ishikawa

213-8587

Toranomon Branch Hospital, Kanagawa

241-8515

Kanagawa Cancer Center, Kanagawa

252-0375

Kitasato University Hospital, Kanagawa

602-8566

University Hospital Kyoto Prefectural University of Medicine, Kyoto

606-8507

Kyoto University Hospital, Kyoto

028-3695

Iwate Medical University Hospital, Numakunai

565-0871

The University of Osaka Hospital, Osaka

589-8511

Kindai University Hospital, Osaka

329-0498

Jichi Medical University Hospital, Tochigi

105-8470

Toranomon Hospital, Tokyo

180-8610

Japanese Red Cross Musashino Hospital, Tokyo

03100

OncoMed, Mexico City

06720

Centro Medico Nacional Siglo Xxi - Imss, Mexico City

41-400

ID Clinic, Mysłowice

02-034

NIO im Marii Sklodowskiej-Curie, Warsaw

00935

PanOncology Trials, San Juan

0700

Limpopo Cancer Research Institute, Polokwane

003-722

Severance Hospital, Yonsei University Health System, Seoul

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08035

Hospital Universitari Vall d'Hebron, Barcelona

08907

Hospital Duran i Reynals, Barcelona

00704

National Cheng Kung University Hospital, Tainan City

01220

Adana Baskent University Medical Faculty, Adana

06490

Ankara Bilkent City Hospital, Ankara

06500

Gazi Uni Medical Faculty Hospital, Ankara

EH4 2XU

Western General Hospital, Edinburgh

NW3 2QG

Royal Free Hospital, London

W12 0HS

Hammersmith Hospital, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Chugai Pharmaceutical

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY