Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML

PHASE2RecruitingINTERVENTIONAL
Enrollment

146

Participants

Timeline

Start Date

April 7, 2024

Primary Completion Date

September 30, 2028

Study Completion Date

September 30, 2028

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Venetoclax plus Azacitidine

"Induction cycle 1:~100 mg venetoclax p.o. on day 1; 200 mg venetoclax p.o. on day 2; 400 mg venetoclax p.o. on days 3-28; 75 mg/m\^2 azacitidine s.c. on days 1-7~Induction cycles 2-3:~400 mg venetoclax p.o. on days 1-28; 75 mg/m\^2 azacitidine s.c. on days 1-7~Postremission cycles 1-9:~400 mg venetoclax p.o. on days 1-28; 75 mg/m\^2 azacitidine s.c. on days 1-7"

DRUG

standard of care chemotherapy plus gemtuzumab ozogamicin

"Induction cycle 1:~200 mg/m\^2 cytarabine cont inf i.v. on days 1-7; 60 mg/m\^2 daunorubicin i.v. on days 3-5; 3 mg/m\^2 (max 1 vial) gemtuzumab ozogamicin i.v. on days 1+4+7~Induction cycle 2 (patients not in remission, moderate or non-responders):~3000/1000 mg/m\^2 cytarabine i.v. BID on days 1-3; 10 mg/m\^2 mitoxantrone i.v. on days 3-5~Postremission cycles 1-3:~3000/1000 mg/m\^2 cytarabine i.v. BID on days 1-3"

Trial Locations (18)

24105

RECRUITING

Universitätsklinikum Schleswig-Holstein, Kiel

35043

RECRUITING

Philipps-Universität Marburg Fachbereich Medizin, Marburg

45147

RECRUITING

Universitätsklinikum Essen, Essen

48149

RECRUITING

Universitätsklinikum Münster, Münster

50937

NOT_YET_RECRUITING

Universiätsklinikum Köln, Cologne

52074

RECRUITING

Universitätsklinikum Aachen, Aachen

60590

RECRUITING

Johann Wolfgang Goethe-Universität, Frankfurt am Main

68167

RECRUITING

Klinikum Mannheim gGmbH, Mannheim

69120

RECRUITING

Universitätsklinikum Heidelberg, Heidelberg

70376

RECRUITING

Robert-Bosch-Krankenhaus, Stuttgart

86156

RECRUITING

Universitätsklinikum Augsburg, Augsburg

90419

RECRUITING

Klinikum Nürnberg-Nord, Nuremberg

91054

RECRUITING

Universitätsklinikum Erlangen, Erlangen

93049

RECRUITING

Krankenhaus Barmherzige Brüder, Regensburg

09116

RECRUITING

Klinikum Chemnitz gGmbH, Chemnitz

01307

RECRUITING

Universitätsklinikum Dresden, Dresden

06120

RECRUITING

Universitätsklinikum Halle, Halle

04103

RECRUITING

Universitätsklinikum Leipzig, Leipzig

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University Hospital Heidelberg

OTHER

collaborator

AbbVie

INDUSTRY

lead

Technische Universität Dresden

OTHER