Diaphragmatic Function as a Biomarker

RecruitingOBSERVATIONAL
Enrollment

800

Participants

Timeline

Start Date

July 1, 2023

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2025

Conditions
Dyspnea; AsthmaticCOPDFibrosisPulmonary HypertensionAsthmaDyspnea
Interventions
DIAGNOSTIC_TEST

Diaphragm Ultrasound

Ultrasound of the Diaphragm at the end of inspiration and expiration

DIAGNOSTIC_TEST

Intercostal Muscle Ultrasound

Ultrasound of the Intercostal Muscles at the end of inspiration and expiration

DIAGNOSTIC_TEST

Borg scale

Questionnaire for Perceived Exertion (Borg Rating of Perceived Exertion Scale)

DIAGNOSTIC_TEST

MRC Breathlessness Scale

The MRC Dyspnoea Scale allows the patients to indicate the extent to which their breathlessness affects their mobility.

DIAGNOSTIC_TEST

Respiratory Questionaire

Specialized respiratory questionnaire with different domains (Emotional Domain, Dyspnea Domain, Mastery Domain, Fatigue Domain)

DIAGNOSTIC_TEST

GINA classification of Asthma

Patients are classified according to the GINA classification of Asthma.

DIAGNOSTIC_TEST

Measurement of respiratory mouth pressure

Inspiratory and expiratory Measurement of respiratory mouth pressure

DIAGNOSTIC_TEST

SNIP

Measurement of Sniff Nasal Inspiratory Pressure

DIAGNOSTIC_TEST

6-minute walking distance

The maximum walking distance achieved in 6 minutes

DIAGNOSTIC_TEST

60 seconds sit-to-stand test

number of repetitions achieved in sitting down and standing up in 60 seconds

DIAGNOSTIC_TEST

Electromyography

electromyography of the muscles of respiration via superficial electrodes

DIAGNOSTIC_TEST

Lung Function

Measurement of lung function via body plethysmography

DIAGNOSTIC_TEST

CAT-Questionnaire

COPD Assessment Test (CAT)

DIAGNOSTIC_TEST

European Society of Cardiology (ESC)/ European Respiratory Society (ERS) risk group

Patients with pulmonary hypertension are classified according to the ESC/ERS risk group.

Trial Locations (1)

52074

RECRUITING

RWTH Aachen University Hospital, Aachen

All Listed Sponsors
lead

RWTH Aachen University

OTHER