NCT05896839 - Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

July 24, 2024

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions

Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8Metastatic Basal Cell CarcinomaMetastatic Carcinoma in the SkinMetastatic MelanomaMetastatic Merkel Cell CarcinomaMetastatic Skin Squamous Cell CarcinomaUnresectable Basal Cell CarcinomaUnresectable MelanomaUnresectable Merkel Cell CarcinomaUnresectable Skin Squamous Cell Carcinoma

Interventions

PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT scan

BIOLOGICAL

Ipilimumab

Given IV

PROCEDURE

Kidney Biopsy

Undergo kidney biopsy

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Nivolumab

Given IV

DRUG

Prednisone

Given PO

DRUG

Sirolimus

Given PO

Trial Locations (25)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20016

RECRUITING

Sibley Memorial Hospital, Washington D.C.

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

60611

RECRUITING

Northwestern University, Chicago

62269

RECRUITING

Memorial Hospital East, Shiloh

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

90020

RECRUITING

Keck Medicine of USC Koreatown, Los Angeles

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH