NCT05895344View on ClinicalTrials.gov

Long-term Cognitive and Functional Impact of Proton-therapy or Modern Fractionated Radiotherapy in Cavernous Sinus Meningioma: An Open-label Randomized 1:1 Phase III Study

NARecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

February 26, 2024

Primary Completion Date

February 29, 2032

Study Completion Date

August 31, 2032

Conditions
Cavernous Sinus MeningiomaProton-therapyPhoton RadiotherapyCognitive Impairment
Interventions
RADIATION

Proton-therapy

Proton pencil-beam-scanning irradiation (50,4 Gy (RBE) in 28 fractions)

RADIATION

Photon radiotherapy

Intensity modulated radiotherapy with or without stereotactic positioning (50,4 Gy in 28 fractions)

Trial Locations (13)

14000

RECRUITING

Centre Francois Baclesse, Caen

Unknown

NOT_YET_RECRUITING

Hopital d'Instruction des Armées PERCY, Clamart

NOT_YET_RECRUITING

CHU Grenoble-Alpes, Grenoble

NOT_YET_RECRUITING

Centre Guillaume le Conquerant, Le Havre

NOT_YET_RECRUITING

Centre Léon Bérard, Lyon

NOT_YET_RECRUITING

Hospices civils de Lyon, Lyon

NOT_YET_RECRUITING

Centre Antoine Lacassagne, Nice

NOT_YET_RECRUITING

Hôpital Pitié Salpétrière, Paris

RECRUITING

Institut Curie, Paris

NOT_YET_RECRUITING

Institut Curie, Saint-Cloud

NOT_YET_RECRUITING

Centre Paul Strauss, Strasbourg

RECRUITING

IUCT, Toulouse

NOT_YET_RECRUITING

Gustave Rousy, Villejuif

All Listed Sponsors
collaborator

National Cancer Institute, France

OTHER_GOV

lead

Centre Francois Baclesse

OTHER