A Neurosensory Account of Anxiety and Stress (Study 1)

NARecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

April 5, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Posttraumatic Stress Disorder (PTSD)Intrinsic and Novelty-related Sensory Cortical (SC) Disinhibition
Interventions
DEVICE

Alternating Current Stimulation (tACS)

A weak electrical current will be passed through the scalp over targeted cortical regions via a transcranial electrical stimulation system (Soterix Medical, Inc), for a span of 10 to 40 minutes at a time. Participants will receive a 2 milliamp (mA) sinusoidal current oscillating at individual participants' baseline peak alpha frequencies (PAF; 7-13 Hz), which will be determined by a 3-min resting state EEG recording during the setup. Current intensities will be modified to address individual participants' subjective reports of discomfort, with a maximum intensity of 2 mA. Stimulation electrodes will be placed within an EEG cap fitted over the participant's head.

DEVICE

Sham for Transcranial Alternating Current Stimulation (tACS)

Stimulation electrodes will be placed on the scalp, but no current will be passed. Stimulation electrodes will be placed within an EEG cap fitted over the participant's head.

DEVICE

Transcranial Random Noise stimulation (tRNS)

A weak electrical currents will be passed through the scalp over targeted cortical regions via a transcranial electrical stimulation system (Soterix Medical, Inc), for a span of 10 to 40 minutes at a time. Participants will receive a 2 mA sinusoidal current oscillating at random frequency (1-200 Hz). Current intensities will be modified to address individual participants' subjective reports of discomfort, with a maximum intensity of 2 mA. Stimulation electrodes will be placed within an EEG cap fitted over the participant's head.

Trial Locations (1)

77030

RECRUITING

The University of Texas Health Science Center at Houston, Houston

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

The University of Texas Health Science Center, Houston

OTHER