CIETAI and Sequential Radiotherapy in Squamous Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

July 1, 2023

Primary Completion Date

February 1, 2025

Study Completion Date

June 1, 2026

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
PROCEDURE

bronchial artery interventional therapy

After successful anesthesia, right femoral artery puncture was performed by Seldinger method. 5F-Yashrio catheter is chosen to locate the bronchial artery of the diseased side at the level of the thoracic aortotracheal bifurcation. Angiography was performed (Osu 300mg/ml, 3ml/s, total 8ml, 200Psi) to visualize tumor blood supply artery before infusion of chemo+PD-1 inhibitor and embolism.

DRUG

Chemotherapy drug

Nano-paclitaxel 260 mg/m2, d1, ivgtt, q3w+Cisplatin 75mg/m2, d1, ivgtt,q3w.

RADIATION

IMRT

60Gy/2Gy/30f

DRUG

Immunotherapy

PD-1 inhibitor (Tirelizumab) 200mg, d1, ivgtt, 30-60min, q3w.

Trial Locations (1)

400042

RECRUITING

Daping Hospital, Third Military Medical University, Chongqing

All Listed Sponsors
lead

Dong Wang

OTHER