Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

PHASE2RecruitingINTERVENTIONAL
Enrollment

227

Participants

Timeline

Start Date

September 26, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

January 31, 2029

Conditions
Grade 3b Follicular LymphomaHigh Grade B-Cell LymphomaHigh Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 RearrangementsRecurrent Diffuse Large B-Cell LymphomaRefractory Diffuse Large B-Cell LymphomaTransformed Non-Hodgkin Lymphoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo optional collection of blood

PROCEDURE

Computed Tomography

Undergo PET/CT and CT

DRUG

Lenalidomide

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

BIOLOGICAL

Tafasitamab

Given IV

DRUG

Tazemetostat

Given PO

DRUG

Zanubrutinib

Given PO

Trial Locations (104)

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

14580

RECRUITING

Wilmot Cancer Institute at Webster, Webster

14642

RECRUITING

University of Rochester, Rochester

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

29425

RECRUITING

Medical University of South Carolina, Charleston

33140

SUSPENDED

Mount Sinai Medical Center, Miami Beach

33308

RECRUITING

Holy Cross Hospital, Fort Lauderdale

39216

RECRUITING

University of Mississippi Medical Center, Jackson

46307

RECRUITING

Northwest Cancer Center - Main Campus, Crown Point

46311

RECRUITING

Northwest Oncology LLC, Dyer

46312

RECRUITING

Saint Catherine Hospital, Indianapolis

46321

RECRUITING

The Community Hospital, Munster

RECRUITING

Women's Diagnostic Center - Munster, Munster

46342

RECRUITING

Northwest Cancer Center - Hobart, Hobart

RECRUITING

Saint Mary Medical Center, Hobart

46383

RECRUITING

Northwest Cancer Center - Valparaiso, Valparaiso

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

50023

SUSPENDED

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50314

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

SUSPENDED

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

SUSPENDED

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

52403

RECRUITING

Mercy Hospital, Cedar Rapids

RECRUITING

Oncology Associates at Mercy Medical Center, Cedar Rapids

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53066

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54241

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60612

RECRUITING

University of Illinois, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Memorial Hospital East, Shiloh

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

Ben Taub General Hospital, Houston

78229

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90211

RECRUITING

Tower Cancer Research Foundation, Beverly Hills

90503

RECRUITING

City of Hope South Bay, Torrance

90813

RECRUITING

City of Hope at Long Beach Elm, Long Beach

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

91030

RECRUITING

City of Hope South Pasadena, South Pasadena

91786

RECRUITING

City of Hope Upland, Upland

92648

RECRUITING

City of Hope Seacliff, Huntington Beach

92660

RECRUITING

City of Hope Newport Beach, Newport Beach

93534

RECRUITING

City of Hope Antelope Valley, Lancaster

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

Sponsors
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

BeiGene

INDUSTRY

collaborator

Ipsen

INDUSTRY

collaborator

Incyte Corporation

INDUSTRY

lead

SWOG Cancer Research Network

NETWORK

NCT05890352 - Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment | Biotech Hunter | Biotech Hunter