Dopamine and Cognition

NACompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

September 23, 2021

Primary Completion Date

July 12, 2022

Study Completion Date

July 12, 2022

Conditions
Sulpiride's Effect on Striatal BOLD Signal During Working Memory GatingInteraction of Sulpiride, Average Reward Rate and Evidence AccumulationInteraction of Sulpiride, Average Reward Rate and Cognitive Effort
Interventions
DRUG

Sulpiride 400 MG

All participants will receive one single dose of 400mg sulpiride. None of the participants will receive repeated doses. In order for the fMRI data acquisition to coincide with the time-window of maximal drug effects represented by a combination of plasma kinetics and physiological effects we will administer the drug 90 minutes prior to fMRI data acquisition.

DRUG

Placebo

All participants will receive placebo during one of the sessions.

Trial Locations (1)

Unknown

Donders Centre for Cognition, Radboud University, Nijmegen

All Listed Sponsors
collaborator

Prof. Dr. Robbert-Jan Verkes, Radboud University Medical Centre Department of Psychiatry

UNKNOWN

collaborator

Funding: NWO + KNAW

UNKNOWN

lead

Donders Centre for Cognitive Neuroimaging

OTHER

NCT05884671 - Dopamine and Cognition | Biotech Hunter | Biotech Hunter