Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement

PHASE4CompletedINTERVENTIONAL
Enrollment

124

Participants

Timeline

Start Date

June 29, 2023

Primary Completion Date

July 8, 2024

Study Completion Date

July 8, 2024

Conditions
HemodynamicsTranscatheter Aortic Valve ReplacementGeneral AnesthesiaPost-induction Hypotension
Interventions
DRUG

ciprofol

"induction of anesthesia:group ciprofol received an IV injection of ciprofol at a dose of 0.2-0.4 mg/kg, and administration time of 30 s.When the eyelash reflex disappeared and the BIS value was ≤60 administration was stopped, followed by an IV injection of alfentanil 30 μg/kg and rocuronium 0.6 mg/kg.~Maintenance of anesthesia: group ciprofol received an IV infusion of ciprofol 0.8-2.4 mg·kg-1·h-1."

DRUG

propofol

"induction of anesthesia:group propofol received an IV injection of propofol at a dose of 1.0-2.0 mg/kg, and administration time of 30 s. When the eyelash reflex disappeared and the BIS value was ≤60 administration was stopped, followed by an IV injection of alfentanil 30 μg/kg and rocuronium 0.6 mg/kg.~Maintenance of anesthesia:group propofol received an IV infusion of propofol 4-6 mg·kg-1·h-1."

Trial Locations (1)

310000

The Second Affiliated Hospital of Zhejiang University anesthesiology department, Hangzhou

All Listed Sponsors
lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER