Melatonin and Response to Lithium

RecruitingOBSERVATIONAL
Enrollment

60

Participants

Timeline

Start Date

July 26, 2023

Primary Completion Date

July 31, 2026

Study Completion Date

July 31, 2026

Conditions
Bipolar Disorder I
Interventions
DIAGNOSTIC_TEST

urine collection

"* Urine collection will be made on a 12 hours period (20h00-8h00), the night before V2~* at V2 : 2 mL urinal sample for measure of 6-SMT concentration (ng/mL) and creatinin (mg/mL)~* Measure of 6-SMT will be made by a validated radio-immunology assay"

DIAGNOSTIC_TEST

Level of Proteins

"* blood sample at V2 (2x3.5mL citrate tubes)~* measured by ELISA"

DIAGNOSTIC_TEST

Level of mRNA and miRNA

"* blood sample at V2 (2x2.5mL PAX-gene tube)~* measured by quantitative RT-PCR"

DIAGNOSTIC_TEST

Level of plasmatic and intraerythrocytic lithium

"* blood sample at V2 (mmol/L)~* 4mL EDTA tube"

Trial Locations (1)

75010

RECRUITING

Hôpital Fernand-Widal, Paris

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER