Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

NARecruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

September 19, 2025

Primary Completion Date

November 1, 2028

Study Completion Date

December 1, 2028

Conditions
Major Depressive DisorderApathy
Interventions
BEHAVIORAL

Targeted Cognitive Training Intervention

In this intervention, participants will complete 25-30 minutes of cognitive training per day, 5 days/week (but up to 7 days/week) for 4 weeks. The training protocol will be delivered via the Posit Science Platform, and includes tasks that emphasize training of sustained attention, salience detection, and dimensions of cognitive control. During the 4 week intervention, participants will have weekly 10-20 minute visits with a Care Manager to provide clinical monitoring of symptoms and structured support to participants.

BEHAVIORAL

General Cognitive Training Intervention

In this intervention, participants will complete 25-30 minutes of cognitive activities per day, 5 days/week (but up to 7 days/week) for 4 weeks. The training protocol will be delivered via the Posit Science Platform. The intervention protocol will include computerized cognitive activities designed to provide general cognitive stimulation. During the 4 week intervention, participants will have weekly 10-20 minute visits with a Care Manager to provide clinical monitoring of symptoms and structured support to participants.

Trial Locations (1)

32804

RECRUITING

AdventHealth Neuroscience Institute, Orlando

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

AdventHealth

OTHER