Combining VNS with PT Interventions for Individuals with PD

NACompletedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

September 1, 2023

Primary Completion Date

July 25, 2024

Study Completion Date

December 1, 2024

Conditions
Parkinson Disease
Interventions
DEVICE

taVNS

Trans-auricular Vagus Nerve Stimulation is a non-invasive method of stimulating the auricular branch of the vagus nerve through the inner ear. Trans-auricular Vagus Nerve Stimulation will be provided using a commercially available device. The investigators will use custom earbuds that will make the experience significantly more comfortable than traditional transauricular Vagus Nerve Stimulation.

BEHAVIORAL

Exercise

All participants will be guided through exercises led by a trained exercise specialist, and will include: 1) intensive exercises that focus on increasing the size and amplitude of movements; 2) task-specific practice, which involves practicing functional tasks, such as dressing, bathing, and cooking, in order to transfer the gains made in therapy to real-life situations. The exercise intervention proposed involves the supervision of a licensed PT at all times during the treatment session. Exercise will be provided in a clinical setting, 45 minutes per session, up to 3 sessions/week, for 4-6 weeks total.

Trial Locations (2)

35209

WHARF, Birmingham

35233

UAB, Birmingham

All Listed Sponsors
lead

University of Alabama at Birmingham

OTHER

NCT05871151 - Combining VNS with PT Interventions for Individuals with PD | Biotech Hunter | Biotech Hunter