A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

PHASE1RecruitingINTERVENTIONAL
Enrollment

270

Participants

Timeline

Start Date

September 13, 2023

Primary Completion Date

August 29, 2028

Study Completion Date

August 29, 2028

Conditions
Systemic Lupus ErythematosusIdiopathic Inflammatory MyopathySystemic SclerosisRheumatoid Arthritis
Interventions
DRUG

CC-97540

Specified dose on specified days

DRUG

Fludarabine

Specified dose on specified days

DRUG

Cyclophosphamide

Specified dose on specified days

DRUG

Tocilizumab

Specified dose on specified days

Trial Locations (54)

3000

RECRUITING

UZ Leuven, Leuven

10016

RECRUITING

NYU Langone Health, New York

10021

WITHDRAWN

Local Institution - 0054, New York

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

10032

RECRUITING

Columbia University Irving Medical Center, New York

10065

WITHDRAWN

Local Institution - 0055, New York

10117

RECRUITING

Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin

14004

RECRUITING

Hospital Universitario Reina Sofia, Córdoba

20089

RECRUITING

Humanitas, Rozzano

21287

WITHDRAWN

Local Institution - 0030, Baltimore

27599

RECRUITING

The University of North Carolina at Chapel Hill, Chapel Hill

29011

RECRUITING

H.R.U Málaga - Hospital General, Málaga

32224

RECRUITING

Mayo Clinic in Florida, Jacksonville

33136

RECRUITING

University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami

33600

RECRUITING

CHU Bordeaux Haut-Leveque, Pessac

34295

RECRUITING

CHU Montpellier Lapeyronie Hospital, Montpellier

35033

RECRUITING

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes

39008

RECRUITING

Hospital Universitario Marqués de Valdecilla, Santander

39120

RECRUITING

Universitaetsklinikum Magdeburg, Magdeburg

40225

RECRUITING

Universitaetsklinikum Duesseldorf, Düsseldorf

43203

WITHDRAWN

Local Institution - 0027, Columbus

44195

RECRUITING

Cleveland Clinic, Cleveland

48202

RECRUITING

Henry Ford Medical Center - New Center One, Detroit

50937

RECRUITING

Universitaetsklinikum Koeln, Cologne

55905

RECRUITING

Mayo Clinic in Rochester, Minnesota, Rochester

59037

RECRUITING

Hopital Claude Huriez - CHU de Lille, Lille

60612

RECRUITING

University of Illinois at Chicago, Chicago

63110

RECRUITING

Washington University School of Medicine, St Louis

67098

NOT_YET_RECRUITING

Local Institution - 0043, Strasbourg

68198

RECRUITING

University Of Nebraska Medical Center, Omaha

75010

RECRUITING

Hôpital Saint-Louis, Paris

75390

RECRUITING

UT Southwestern Medical Center, Dallas

75679

WITHDRAWN

Local Institution - 0052, Paris

77030

RECRUITING

The University of Texas Health Science Center at Houston, Houston

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

80045

RECRUITING

University of Colorado Anschutz Medical Campus, Aurora

80218

RECRUITING

Colorado Blood Cancer Institute, Denver

91054

RECRUITING

Universitaetsklinikum Erlangen, Erlangen

97080

RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

98104

RECRUITING

Swedish Medical Center, Seattle

98105

NOT_YET_RECRUITING

Local Institution - 0057, Seattle

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

06520

WITHDRAWN

Local Institution - 0048, New Haven

02115

NOT_YET_RECRUITING

Local Institution - 0038, Boston

WITHDRAWN

Local Institution - 0046, Boston

01655

NOT_YET_RECRUITING

University of Massachusetts Chan Medical School, Worcester

RECRUITING

University of Massachusetts Chan Medical School, Worcester

48109-2800

RECRUITING

University of Michigan, Ann Arbor

07901

RECRUITING

Atlantic Health System Overlook Medical Center, Summit

06202

RECRUITING

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice

04103

RECRUITING

Universitätsklinikum Leipzig, Leipzig

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

08036

RECRUITING

Hospital Clínic de Barcelona, Barcelona

All Listed Sponsors
collaborator

Bristol-Myers Squibb Services Unlimited Company

UNKNOWN

lead

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

INDUSTRY