RewinD-LB - Clinical Study of Neflamapimod in Patients With Dementia With Lewy Bodies

PHASE2CompletedINTERVENTIONAL
Enrollment

159

Participants

Timeline

Start Date

May 1, 2023

Primary Completion Date

October 4, 2024

Study Completion Date

June 16, 2025

Conditions
Dementia With Lewy Bodies
Interventions
DRUG

Neflamapimod

Neflamapimod is a highly specific inhibitor of the intra-cellular enzyme mitogen-activated protein kinase14 (p38α) provided in 40mg capsules

DRUG

Placebo

Placebo is a capsule that looks just like neflamapimod but without the active ingredients

Trial Locations (40)

1081

Brain Research Center - Amsterdam, Amsterdam

5223

Brain Research Center - Den Bosch, 's-Hertogenbosch

8025

Brain Research Center - Zwolle, Zwolle

10032

Columbia University - Taub Institute/Neurology Dept, New York

20007

Georgetown Univ Hospital - Dept of Neurology, Washington D.C.

21287

Johns Hopkins School of Medicine - Dept of Neurology, Baltimore

22205

Sana Research, Arlington

23298

Virginia Commonwealth University - Parkinson's and Movement Disorders Center, Richmond

27599

University of North Carolina - Dept of Neurology, Chapel Hill

32503

Panhandle Research and Medical Clinic, Pensacola

32804

AdventHealth Neuroscience Research, Orlando

32940

ClinCloud, Melbourne

33462

JEM Research Institute, Lake Worth

43221

Ohio State University - Dept of Neurology, Columbus

44195

Cleveland Clinic - Center for Brain Health, Cleveland

44718

NeuroScience Research Center, Canton

55905

Mayo Clinic - Alzheimer's Disease Research Center, Rochester

66160

University of Kansas Medical Center, Kansas City

68198

University of Nebraska Medical Center - Dept of Neurological Sciences, Omaha

70072

Tandem Clinical Research, Marrero

77030

Houston Methodist Hospital - Stanley Appel Neurology Dept, Houston

80045

University of Colorado - Dept of Neurology, Aurora

85013

Barrow Neurological Institute, Phoenix

85351

Banner Sun Health Research Institute, Sun City

85718

Banner Alzheimer's Institute - Edson Family Lewy Body Dementia Center, Tucson

89106

Cleveland Clinic - Lou Ruvo Center for Brain Health, Las Vegas

91105

SC3 Research Group, Pasadena

92037

UCSD Health Sciences - Movement Disorders Center, La Jolla

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

94304

Stanford Neuroscience Health Center, Palo Alto

97225

Center for Cognitive Health, Portland

02129

Mass General Hospital/Harvard Medical School - Dept of Neurology, Charlestown

BT12 6BA

Belfast Health & Social Care Trust, Belfast

CB215EF

Cambridgeshire and Peterborough NHS Foundation Trust, Fulbourn Hospital - Windsor Research Unit, Cambridge

SE5 8AF

South London and Maudsley NHS Foundation Trust, London

W1G9JF

Re:Cognition Health, London

WC1N 3BG

University College London (UCL) Clinical Research Facility, University College London Hospitals NHS Foundation Trust, London

NE4 5PL

Campus Ageing Research Unit (CARU) - Newcastle upon Tyne, CNTW NHS Foundation Trust, Newcastle upon Tyne

TR15 3QE

Cornwall Partnership NHS Foundation Trust (University of Exeter), Redruth

SO30 3JB

Memory Assessment and Research Centre (MARC) - Moorgreen Hospital, Southampton

Sponsors
All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

collaborator

Worldwide Clinical Trials

OTHER

collaborator

CervoMed, Inc

UNKNOWN

lead

EIP Pharma Inc

INDUSTRY