Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

408

Participants

Timeline

Start Date

October 19, 2023

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2034

Conditions
Metastatic Colorectal CarcinomaMetastatic Malignant Neoplasm in the LiverStage IV Colorectal Cancer AJCC v8Unresectable Colorectal Carcinoma
Interventions
BIOLOGICAL

Bevacizumab

Given IV

BIOLOGICAL

Cetuximab

Given IV

PROCEDURE

Computed Tomography

Undergo SPECT/CT and/or CT

DRUG

Floxuridine

Given via HAI pump

DRUG

Fluorouracil

Given IV

PROCEDURE

Implantation

Undergo surgery to place the HAI pump

PROCEDURE

Intrahepatic Infusion Procedure

Undergo HAI

DRUG

Irinotecan

Given IV

DRUG

Leucovorin

Given IV

DRUG

Oxaliplatin

Given IV

BIOLOGICAL

Panitumumab

Given IV

PROCEDURE

Single Photon Emission Computed Tomography

Undergo SPECT/CT

Trial Locations (39)

10029

RECRUITING

Mount Sinai Hospital, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, East White Plains

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Commack, Commack

15212

RECRUITING

Allegheny General Hospital, Pittsburgh

15224

RECRUITING

West Penn Hospital, Pittsburgh

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

27710

RECRUITING

Duke University Medical Center, Durham

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

33021

RECRUITING

UM Sylvester Comprehensive Cancer Center at Hollywood, Hollywood

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

44106

ACTIVE_NOT_RECRUITING

Case Western Reserve University, Cleveland

46032

RECRUITING

IU Health North Hospital, Carmel

46202

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

62269

RECRUITING

Memorial Hospital East, Shiloh

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

75235

RECRUITING

Parkland Memorial Hospital, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen, Montvale

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

ECOG-ACRIN Cancer Research Group

NETWORK