Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study

NARecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

May 29, 2023

Primary Completion Date

May 25, 2029

Study Completion Date

May 25, 2029

Conditions
Cervical CancerEndometrial Cancer
Interventions
RADIATION

Hypofractionated Image guided External Beam Radiation Therapy (EBRT)

"External beam radiotherapy to pelvis:~Post operative hypofractionated external beam radiotherapy with intensity modulated/arc technique, to a dose of 39 Gy in 13 fractions, at 3 Gy per fraction, delivered once daily, 5 days a week, over 2.5-3 weeks."

DRUG

Cisplatin

Patients who require adjuvant chemotherapy along with radiation, based on predefined risk features, will receive 5 cycles of cisplatin on a weekly basis with a dose of 40 mg/m2 by IV infusion over a period of 1 hour 2-4 hours prior to start of EBRT.

RADIATION

Vaginal brachytherapy

Vaginal brachytherapy, two fractions of 6 Gy each, delivered 1 week apart.

Trial Locations (2)

400012

RECRUITING

Tata Memorial Hospital, Mumbai

410210

RECRUITING

Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Navi Mumbai

All Listed Sponsors
lead

Tata Memorial Centre

OTHER