Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery

PHASE4RecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

June 15, 2023

Primary Completion Date

June 1, 2025

Study Completion Date

June 1, 2025

Conditions
Stress Disorders, Post-Traumatic
Interventions
BEHAVIORAL

Memory reactivation procedures

In the Mismatch condition, a different, unexpected mismatch will be incorporated into the reactivation. In the Standard condition, the participant will read the narrative the same way each time.

DRUG

Propranolol

Propranolol will be administered 60-min prior to each of six weekly 10-20 min. traumatic memory reactivation sessions.

Trial Locations (1)

02129

RECRUITING

Massachusetts General Hospital Home Base Program, Charlestown

All Listed Sponsors
lead

Massachusetts General Hospital

OTHER