buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

August 7, 2023

Primary Completion Date

November 30, 2026

Study Completion Date

April 30, 2027

Conditions
Hypoxia-Ischemia, BrainHeart ArrestStatus EpilepticusRefractory Status EpilepticusSeizuresAnoxic-Ischemic EncephalopathyAnoxia-Ischemia, Cerebral
Interventions
DRUG

Burst Suppression EEG Target Intravenous Anesthesia

The objective of the burst suppression EEG target is to stop seizures by titrating the anesthetic infusion to suppress most of the EEG background (\>50% suppressed/attenuated). After this 24-hour period, this target would be continued for 24 hours. The anesthetic will then be tapered under EEG monitoring. In case of PCARSE recurrence, the intervention with the same target will be re-initiated for another cycle of 24 hours.

DRUG

Seizure Suppression EEG Target Intravenous Anesthesia

is to stop seizures by titrating the anesthetic infusion without suppressing most of the EEG background. This target would be continued for 24 hours. After this 24-hours period, this target would be continued for 24 hours. The anesthetic will then be tapered under EEG monitoring. In case of PCARSE recurrence, the intervention with the same target will be re-initiated for another cycle of 24 hours.

Trial Locations (1)

94110

RECRUITING

Zuckerberg San Francisco General Hospital, San Francisco

All Listed Sponsors
collaborator

The ZOLL Foundation

UNKNOWN

lead

University of California, San Francisco

OTHER