Effect of Vitis Vinifera Seed Extract on Venous Reflux Time in Varicose Vein

PHASE4CompletedINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

July 20, 2023

Primary Completion Date

September 30, 2024

Study Completion Date

January 30, 2025

Conditions
Varicose Veins of Lower Limb
Interventions
DRUG

Vitis Vinifera seed extract medication plus therapeutic lifestyle change

Administer 150mg of Vitis Vinifera seed extract (Entelon®) orally twice a day

BEHAVIORAL

Therapeutic lifestyle change only

Implementing TLCs is a critical component of a comprehensive treatment plan for varicose veins. A key aspect of TLCs is the optimization of postural habits. Patients are advised to avoid extended sitting or standing periods, which exert additional pressure on the venous system in the lower extremities and exacerbate venous insufficiency. During rest periods, elevating the legs closer to the heart is recommended because this simple yet effective adjustment promotes venous return and reduces the gravitational burden on the venous valves of the legs. The use of graduated compression stockings during waking hours is another therapeutic lifestyle intervention that is often prescribed for patients with varicose veins. Additional TLCs include maintaining optimal body weight and engaging in regular physical exercise Walking or cycling are often recommended because of their effectiveness in promoting lower limb venous return.

Trial Locations (1)

16995

Yongin Severance Hospitall, Yonsei University College of Medicine, Yongin

All Listed Sponsors
lead

Yonsei University

OTHER