892
Participants
Start Date
May 15, 2023
Primary Completion Date
November 7, 2024
Study Completion Date
May 27, 2025
Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose
Intravitreally (IVT) injection.
Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg
Intravitreally (IVT) injection.
Sham
Sham procedure will be given on visits when an active injection is not planned.
Fluorescein
Fluorescein 100 mg/mL solution for injection is a dye that makes the retinal vessels visible during FA examinations, and as such, it will be used as an auxiliary medicinal product (AxMP) in this periodic ophthalmic examination. This medicine is for diagnostic use only. It is not used to treat any condition.
Uni Heidelberg / Augenklinik, Heidelberg
"LTD Chichua Medical Center MZERA", Tbilisi
Fondazione G.B.Bietti Per Lo Studio E La Ricerca In Oftalmologia, Rome
Department of Ophthalmology, Riga
University Eye Hospital Jules Gonin, Lausanne
RétinElysée, Lausanne
Magyar Honvedseg Egeszsegugyi Kozpont, Budapest
University of Semmelweis/ Semmelweis Egyetem, Budapest
Universitätsklinikum AKH Wien, Vienna
Budapesti Bajcsy-Zsilinszky Korhaz es Rendelointezet, Budapest
Budapest Retina Associates, Budapest
Hanusch-Krankenhaus Wien, Vienna
SEHAT Pentagram, Sofia
Specialized Hospital For Active Treatment of Eye Diseases Zora, Sofia
Sydney Eye Hospital, Sydney
Sydney Retina Clinic, Sydney
Strathfield Retina Clinic, Strathfield
Sydney West Retina Pty Ltd, Westmead
Marsden Eye Surgery Center, Parramatta
Eyeclinic Albury Wodonga, Albury
Centre for Eye Research, East Melbourne
Inselspital Universitätsspital Bern, Bern
Seoul National University Hospital, Seoul
Konventhospital Barmherzige Brüder Linz, Linz
Debreceni Egyetem Klinikai Kozpont, Debrecen
Vista Klinik, Binningen
Adelaide Eye and Retina Centre, Adelaide
Lion Eye Institute, Nedlands
SBU Gulhane Egitim ve Arastirma Hastanesi, Ankara
Ankara Numune Egitim ve Arastirma Hastanesi, Ankara
Hacettepe Universitesi Tip Fakultesi, Ankara
Gangnam Severance Hospital, Yonsei University Health System, Seoul
SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont, Szeged
Ankara Bilkent Sehir Hastanesi, Bilkent Ankara
Hobart Eye Surgeons, Hobart
Ganglion Medical Center, Pécs
Hospital de la Santa Creu i de Sant Pau, Barcelona
Medizinische Universität Graz, Graz
Hospital Clínic i Provincial de Barcelona, Barcelona
Spec. Hosp. of Ophthalm. Disease for Active Treatment Varna, Varna
Klinikum Klagenfurt am Wörthersee, Klagenfurt
Adnan Menderes Universitesi Tip fakultesi, Aydin
Fakultní nemocnice Královské Vinohrady - Urologická klinikay, Prague
AS Ida-Tallinna Keskhaigla - Oftalmoloogiakeskus, Tallinn
Clinical Center of Serbia, Belgrade
Clinical hospital center Zvezdara, Belgrade
Long Island Vitreoretinal Consultants - Great Neck, Great Neck
Dr. Kai Noor Silmakabinet OÜ, Tallinn
Ophthalmic Consultants of Long Island, Lynbrook
Vitreoretinal Consultants of NY - Hauppauge, Hauppauge
Všeobecná fakultní nemocnice v Praze, Prague
Centre d'Ophtalmologie - Paradis-Monticelli, Marseille
Seoul National University Bundang Hospital, Seongnam-si
Retina Associates of Western New York, Rochester
Instituto Oftalmologico Gomez-Ulla S.L. - Oftalmologia, Santiago de Compostela
Mid Atlantic Retina - Philadelphia / Wills Eye Hospital, Philadelphia
ASST Fatebenefratelli Sacco, Milan
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan
Ospedale San Raffaele s.r.l., Milan
CHU Dijon - Hopital Francois Miterrand, Dijon
Klinicki centar Vojvodine, Novi Sad
Retina Care Center, Baltimore
Mid Atlantic Retina Specialists - Hagerstown, Hagerstown
Hospital Universitario Puerta De Hierro De Majadahonda - Oftalmologia, Majadahonda
Retina Consultants of South Carolina - Ladson, Ladson
Palmetto Retina Center, LLC - Florence, Florence
Marietta Eye Clinic, Marietta
Clínica Universidad de Navarra CUN, Pamplona
Retina Specialty Institute - Pensacola, Pensacola
Florida Retina Institute - Orlando, Orlando
Florida Eye Associates - Melbourne Main Office, Melbourne
Clinique Rétine Tourny, Bordeaux
Rand Eye Institute, Deerfield Beach
CHU Bordeaux - Hopital Pellegrin - Ophtalmologie, Bordeaux
Fort Lauderdale Eye Institute, Plantation
Retina Vitreous Associates of Florida - Saint Petersburg, St. Petersburg
The Eye Institute of West Florida, Largo
Center for Retina and Macular Disease - Winter Haven, Winter Haven
National Ophthalmic Research Institute - Fort Myers, Fort Myers
East Florida Eye Institute, Stuart
Centre Ophtalmologique Transparence - Tours, Tours
Charles Retina Specialists - Germantown, Memphis
Srinagarind Hospital, Khon Kaen
Kocaeli Universitesi Tip Fakultesi, Kocaeli
Yeungnam University Medical Center, Daegu
Midwest Retina - Main Office, Dublin
Clinique Jules Verne - Nantes, Nantes
Hospital General Universitario de Valencia, Valencia
Hospital Universitario Rio Hortega - Oftalmologia, Valladolid
St. Franziskus-Hospital Münster - Eye Center, Münster
Pusan National University Hospital, Busan
Vitreo-Retinal Associates, PC, Grand Rapids
Shijiazhuang General Hospital, Shijiazhuang
Hospital Universitario Miguel Servet - Oftalmologia, Zaragoza
Chiangmai University, Chiang Mai
Sihtasutus Tartu Ülikooli Kliinikum - Silmakliinik, Tartu
Uniklinik Bonn / Eye Clinic, Bonn
University of Wisconsin - Madison, Madison
RCM - St. Louis Park Retina Clinic, Saint Louis Park
OasisEye Specialists, Kuala Lumpur
Retina Associates - Elmhurst, Elmhurst
Azienda Ospedaliero Universitaria Delle Marche - Clinica Oculistica, Torrette
University Retina and Macula Associates, Oak Forest
Retina Associates - Lenexa, Lenexa
Knappschaftskrankenhaus Sulzbach, Sulzbach
CM Wolff, Strasbourg
Klinikum d. Stadt Ludwigshafen - Ophthalmology, Ludwigshafen
Hospital Selayang, Shah Alam
Hôpital de la Croix Rousse, Lyon
Centre d'ophtalmologie de l'Odéon, Paris
Centre Ophthalmologie d'Imagerie et de Laser, Paris
AP-HP - Hopital Lariboisiere, Paris
Centre Hospitalier National d'Ophthalmologie Quinze-Vingt, Paris
Texas Retina Associates, Fort Worth
Retina Consultants of Texas - Bellaire, Bellaire
Medical Center Ophthalmology Associates - Northwest, San Antonio
Retina Consultants of Texas - San Antonio Medical Center, San Antonio
Austin Retina Associates - Central, Austin
Retina Consultants of Southern Colorado, PC, Colorado Springs
Rocky Mountain Retina Consultants - Main Office, Salt Lake City
Eye Associates of New Mexico - Albuquerque - Retina Center, Albuquerque
Retina Consultants of Nevada - Summerlin, Las Vegas
South Coast Retina - Long Beach, Long Beach
Azul Vision Pasadena, Pasadena
Southern California Desert Retina Consultants - Palm Springs Office, Palm Springs
Retina Consultants of Southern California, Redlands
Retina Consultants of Orange County - Fullerton, Fullerton
Hôpital Intercommunal - Créteil Cedex, Créteil
Northern California Retina Vitreous Associates - Mountain View Office, Mountain View
Specialized hospital for ophthalmology OPHTAL, Zvolen
Retina Consultants, LLC, Salem
Fakultna Nemocnica s poliklinikou F.D.Roosevelta, Banská Bystrica
Spokane Eye Clinical Research, Spokane
Beijing Aier Intech Eye Hospital, Beijing
China-Japan Friendship Hospital, Beijing
Peking University First Hospital, Beijing
Capital Medical University (CMU) - Beijing Tongren Hospital, Beijing
Beijing Hospital, Beijing
Peking Union Medical College Hospital CAMS, Beijing
The Fourth People's Hospital of Shenyang, Shenyang
Eye Center of the second Bethune Hospital, jinlin University, Changchun
The Second Hospital of Anhui medical university, Hefei
Qilu Hosp., Shandong Univ., Jinan
Tianjin Medical University Eye Hospital, Tianjin
ZheJiang Provincial People's Hospital, Hangzhou
Dongyang People's Hospital, Jinhua
Chongqing Aier Ophthalmology Hospital, Chongqing
Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech., Wuhan
Henan Provincial Eye Hospital, Henan
Guangzhou Aier Eye Hospital, Guangzhou
Lanzhou University - The Second Hospital (The Second Clinical Medical College of Lanzhou University), Lanzhou
People's Hospital of Ningxia Hui Autonomous Region - Opthalmology, Ningxia
Rambam Health Corporation, Haifa
Lady Davis Carmel Medical Center, Haifa
Meir Medical Center, Kfar Saba
Tel-Aviv Sourasky Medical Center, Tel Aviv
Assuta Medical Centers - HaShalom, Tel Aviv
Shamir Medical Center (Assaf Harofeh), Ẕerifin
Kaplan Medical Center, Rehovot
Hadassah Hebrew University Hospital Ein Kerem, Jerusalem
New England Retina Associates, New London
"Cumberland Valley Retina Consultants , Hagerstown, MD"
Retina Center of New Jersey, Bloomfield
NJ Retina - New Brunswick, New Brunswick
"NJ Retina , Teaneck"
"University of North Carolina at Chapel Hill (UNC) , Ophthalmology"
Cincinnati Eye Institute - Blue Ash, Blue Ash
"The Retina Group of Washington , Fairfax"
Hebei eye hospital, Hebei
Aier Eye Hospital (LIAONING), Shenyang
Aier Eye Hospital (Chengdu), Chengdu
"Clalit Health , Soroka Medical Center - Internal Medicine Department"
"Edith Wolfson Medical Center , Internal Medicine Department"
"Rabin Medical Center , Beilinson Hospital - Internal Medicine C Department"
"Centro Hospitalar Universitario de Sao Joao , Polo Porto - Centro de Investigacao e Ensaios Clinicos"
"Centro Hospitalar Vila Nova de Gaia e Espinho , Unit 1 - Clinical Research Center"
"Ankara Etlik City Hospital , Ophthalmology"
Shanxi Eye Hospital, Shanxi
Fakultní Nemocnice Hradec Kralové, Hradec Králové
Fakultní nemocnice Ostrava, Ostrava
Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice, Pardubice
Lexum a.s., Evropska ocni klinika, Prague
Axon Clinical, s.r.o., Prague
"LTD IQ Clinic- Ophthalmology", Tbilisi
Azienda Ospedaliera Policlinico Universitario Tor Vergata - Patologie Retiniche, Rome
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oculistica, Rome
Aichi Medical University Hospital, Nagakute
Nagoya City University Hospital, Nagoya
International University of Health and Welfare Narita Hospital, Narita
Toho University Sakura Medical Center, Sakura
University of Fukui Hospital, Yoshida
Kurume University Hospital, Kurume
Southern Tohoku Eye Clinic, Kōriyama
Gunma University Hospital, Maebashi
Hyogo Prefectural Amagasaki General Medical Center, Amagasaki
Kobe University Hospital, Kobe
Hyogo Medical University Hospital, Nishinomiya
Kozawa Eye Hospital and Diabetes Center, Mito
Matsumoto Eye Clinic, Toride
Kagawa University Hospital, Kita-gun
Medical corporation Eiwakai Dannoue Ophthalmology clinic, Kawasaki
St. Marianna University Hospital, Kawasaki
Yokohama City University Medical Center, Yokohama
Mie University Hospital, Tsu
Shinshu University Hospital, Matsumoto
National Defense Medical College Hospital, Tokorozawa
Shiga University of Medical Science Hospital, Ōtsu
Shida Eye Clinic, Fujieda-shi
Nihon University Hospital, Chiyoda-ku
The University of Tokyo Hospital, Bunkyo-ku
Chofu Eye Clinic, Chōfu
Tokyo Medical University Hachioji Medical Center, Hachiōji
Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku
Tokiwadai Muranaka Eye Clinic, Itabashi-ku
National Hospital Organization Tokyo Medical Center, Meguro-ku
Keio University Hospital, Shinjuku-ku
Tokyo Women's Medical University Hospital, Shinjuku-ku
Yamaguchi University Hospital, Ube
University of Yamanashi Hospital, Chūō
Akita University Hospital, Akita
Hayashi Eye Hospital, Fukuoka
Murakami Karindoh Hospital, Fukuoka
Fukushima Medical University Hospital, Fukushima
Kagoshima University Hospital, Kagoshima
University of Miyazaki Hospital, Miyazaki
Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki
Okayama University Hospital, Okayama
Osaka Metropolitan University Hospital, Osaka
Japanese Red Cross Saitama Hospital, Saitama
Toyama University Hospital, Toyama
Japanese Red Cross Wakayama Medical Center, Wakayama
Yamagata University Hospital, Yamagata
"Riga East Clinical University Hospital Gailezers", Riga
Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas
Vilnius University Hospital Santaros Klinikos, Vilnius
"Hospital Al-Sultan Abdullah, UiTM , Opthalmology"
"Hospital Shah Alam , Ophthalmology"
Prywatna Klinika Okulistyczna OFTALMIKA, Bydgoszcz
Specjalistyczny Osrodek Okulistyczny Oculomedica, Bydgoszcz
Profesorskie Centrum Okulistyki, Gdansk
Gabinet Okulistyczny Prof. Edward Wylegala, Katowice
Centrum Medyczne Dietla 19 Sp. z o.o., Krakow
Centrum Medyczne PROMED, Krakow
Centrum Diagnostyki i Mikrochirurgii Oka Lens, Olsztyn
Osrodek Chirurgii Oka prof. Zagorskiego Sp. z o.o., Rzeszów
Centrum Medyczne Piasta 47, Wałbrzych
AIBILI, Coimbra
Espaco Medico de Coimbra, Coimbra
CHLC - Hospital dos Capuchos - Servico de Oftalmologia, Lisbon
Centro Hospitalar Universitario do Porto, Porto
Univerzitna nemocnica Bratislava, Nemocnica Ruzinov, Bratislava
Univerzitna nemocnica Bratislava, Nem. Sv. Cyrila a Metoda, Bratislava
Fakultna nemocnica Nitra, Nitra
Fakultna nemocnica Trencin, Trenčín
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Korea University Ansan Hospital, Gyeonggi-do
Samsung Medical Center, Seoul
St. Mary Hospital, Seoul
Kim's Eye Hospital, Seoul
Hospital General de Catalunya - Oftalmologia, Sant Cugat del Vallès
Hospital Vall d'Hebron - Servei d'Oftalmologia, Barcelona
Berner Augenklinik am Lindenhofspital, Bern
Leicester Royal Infirmary, Leicester
Frimley Park Hospital NHS, Frimley
Sunderland Eye Infirmary, Sunderland
New Cross Hospital, Wolverhampton
Bradford Royal Infirmary, Bradford
"Leeds Teaching Hospitals NHS Trust , St James's University Hospital - Oncology"
Hull and East Yorkshire Eye Hospital Hull and East Yorkshire, Hull
Royal Liverpool University Hospital, Liverpool
Moorfields Eye Hospital, London
York Teaching Hospital, York
Lead Sponsor
Regeneron Pharmaceuticals
INDUSTRY
Bayer
INDUSTRY