Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy

PHASE2RecruitingINTERVENTIONAL
Enrollment

284

Participants

Timeline

Start Date

September 4, 2023

Primary Completion Date

May 31, 2029

Study Completion Date

November 30, 2031

Conditions
Relapsed Follicular LymphomaRefractory Follicular Lymphoma
Interventions
DRUG

Epcoritamab

Bispecific antibody

DRUG

Lenalidomide

Immunomodulatory agent

DRUG

Rituximab

Monoclonal antibody

DRUG

Obinutuzumab

Monoclonal antibody

DRUG

Bendamustine

Alkylating agent (chemotherapy drug)

DRUG

Vincristine

Antineoplastic, Vinca Alkaloid

DRUG

Doxorubicin

Anthracycline

DRUG

Cyclophosphamide

Alkylating agent (chemotherapy drug)

DRUG

Prednisone

Corticosteroid

DRUG

Investigation agent 2

The drug used in round 2 is yet to be confirmed, round 2 is estimated to open in Q4 2025 and the record will be updated when the drug has been confirmed

DRUG

Investigation agent 3

The drug used in round 3 is yet to be confirmed, round 3 is estimated to open in Q3 2027 and the record will be updated when the drug has been confirmed

Trial Locations (25)

Unknown

NOT_YET_RECRUITING

NHS Grampian, Aberdeen

NOT_YET_RECRUITING

Belfast Health & Social Care Trust, Belfast

NOT_YET_RECRUITING

University Hospitals Birmingham NHS Foundation Trust, Birmingham

NOT_YET_RECRUITING

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

NOT_YET_RECRUITING

Cambridge University Hospitals NHS Foundation Trust, Cambridge

NOT_YET_RECRUITING

Cardiff and vale University LHB, Cardiff

NOT_YET_RECRUITING

University Hospitals Coventry and Warwickshire NHS Trust, Coventry

NOT_YET_RECRUITING

Croydon Health Services NHS Trust, Croydon

NOT_YET_RECRUITING

NHS Greater Glasgow and Clyde, Glasgow

NOT_YET_RECRUITING

The Leeds Teaching Hospitals NHS Trust, Leeds

NOT_YET_RECRUITING

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

NOT_YET_RECRUITING

Guy's and St Thomas' NHS Foundation Trust, London

NOT_YET_RECRUITING

King's College Hospital NHS Foundation Trust, London

NOT_YET_RECRUITING

The Royal Marsden NHS Foundation Trust, London

NOT_YET_RECRUITING

University College London Hospital NHS Foundation Trust, London

RECRUITING

The Christie NHS Foundation Trust, Manchester

NOT_YET_RECRUITING

The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle

NOT_YET_RECRUITING

Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich

RECRUITING

Nottingham University Hospitals NHS Trust, Nottingham

NOT_YET_RECRUITING

Oxford University Hospitals NHS Foundation Trust, Oxford

NOT_YET_RECRUITING

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

NOT_YET_RECRUITING

University Hospital Southampton NHS Foundation Trust, Southampton

NOT_YET_RECRUITING

University Hospital of North Midlands NHS Trust, Stoke-on-Trent

NOT_YET_RECRUITING

Swansea Bay University Local Health Board, Swansea

NOT_YET_RECRUITING

Torbay and South Devon NHS Foundation Trust, Torquay

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Cancer Research UK

OTHER

collaborator

Genmab

INDUSTRY

lead

University of Birmingham

OTHER