NCT05843877View on ClinicalTrials.gov

Pancreatic Head Resection or Total Pancreatectomy With Islet Autotransplantation in Patients With Periampullary Cancer and High Risk Profile for the Development of Postoperative Pancreatic Fistula

PHASE3RecruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

January 28, 2025

Primary Completion Date

January 31, 2028

Study Completion Date

January 31, 2028

Conditions
Periampullary CancerPostoperative Pancreatic Fistula
Interventions
BIOLOGICAL

Intraportal transplantation of isolated autologous pancreatic islets after total pancreatectomy

Islet cells are isolated from patients healthy pancreatic tissue. Following total pancreatectomy, these autologous cells are injected into the portal vein, to implant in the liver and produce insulin.

PROCEDURE

Pancreaticoduodenectomy (classic Whipple or pylorus-preserving)

As a standard procedure, the tumor-affected region of the pancreatic head with surrounding tissue and lymph nodes is removed during surgery. Reconstruction is performed by pancreaticojejunostomy.

Trial Locations (1)

Unknown

RECRUITING

University Hospital Carl Gustav Carus Technische Universität Dresden, Dresden

All Listed Sponsors
collaborator

German Cancer Research Center

OTHER

lead

Technische Universität Dresden

OTHER