Combination Diuretic Therapy for Acute Decompensated Heart Failure

PHASE4WithdrawnINTERVENTIONAL
0
Timeline

Start Date

May 31, 2014

Primary Completion Date

October 31, 2015

Study Completion Date

October 31, 2015

Conditions
Acute Decompensated Heart Failure
Interventions
DRUG

Furosemide plus Chlorothiazide

"Patients will receive lasix infusion starting at 5mg/hr along with a bolus dose of chlorothiazide 250mg at the initiation of the protocol. The lasix infusion can be titrated to 10mg after 12hrs based on volume of diuresis. This arm will also receive 250mg bolus doses of chlorothiazide every 12hrs for the duration of the study.~Intravenous (IV) lasix infusion at 5mg/hr plus IV boluses of diuril every 12 hrs."

DRUG

Furosemide

Patients will receive furosemide infusion at 5mg/hr along with an initial bolus dose of furosemide equal to twice their home oral dose. The furosemide infusion can be increased to 10mg/hr after 12hrs based on urine output. This arm will receive bolus doses of furosemide every 12hrs equal to twice their home oral dose until completion of the protocol.

Trial Locations (1)

70121

Ochsner Heart and Vascular Institute, New Orleans

Sponsors
All Listed Sponsors
lead

Ochsner Health System

OTHER

NCT05840536 - Combination Diuretic Therapy for Acute Decompensated Heart Failure | Biotech Hunter | Biotech Hunter