Effect of a Transversus Abdominis Plane Block on Wound Healing, Stress, and Immune Response After a Cesarean Delivery

NACompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

September 3, 2024

Primary Completion Date

March 17, 2025

Study Completion Date

March 20, 2025

Conditions
Postoperative PainCesarean SectionWound Heal
Interventions
DRUG

Postoperative pain management with acetaminophen

During the 24 hours postoperatively, participants will receive 1 g acetaminophen intravenously (i.v.) three times a day. On the second and third postoperative days, participants will receive 1g acetaminophen per os three times a day.

PROCEDURE

Bilateral TAP Block with levobupivacaine

Ultrasound-guided bilateral TAP block will be performed, and 20 ml of 0,25 % levobupivacaine will be administered to the participant on each side.

PROCEDURE

Bilateral TAP Block with levobupivacaine and dexmedetomidine

Ultrasound-guided bilateral TAP block will be performed, and 20 ml of 0,25 % levobupivacaine with the addition of 0,5 μg/kg dexmedetomidine will be administered to the participant on each side.

DRUG

Postoperative pain management with tramadol

During the 24 hours postoperatively, participants will receive 500 mg tramadol + 500 ml 0,9% NaCl i.v. continuously 30ml/h.

DRUG

Postoperative pain management with ketoprofen

During the 24 hours postoperatively, participants will receive 100 mg ketoprofen + 100 ml of 0,9% NaCl i.v. twice a day. The first dose will be administered in the theatre at the end of the surgical procedure.

DRUG

Postoperative pain management with ibuprofen

On the second and third postoperative days, participants will receive 600 mg ibuprofen per os three times a day.

Trial Locations (1)

10000

University Hospital Center Sestre milosrdnice, Zagreb

All Listed Sponsors
lead

University Hospital Sestre Milosrdnice

OTHER

NCT05840406 - Effect of a Transversus Abdominis Plane Block on Wound Healing, Stress, and Immune Response After a Cesarean Delivery | Biotech Hunter | Biotech Hunter