48
Participants
Start Date
March 28, 2024
Primary Completion Date
September 30, 2028
Study Completion Date
September 30, 2028
Biospecimen Collection
Undergo collection of blood and urine samples
Bone Marrow Aspiration
Undergo bone marrow aspiration
Bone Marrow Biopsy
Undergo bone marrow biopsy
Computed Tomography
Undergo CT
Echocardiography Test
Undergo ECHO
FDG-Positron Emission Tomography and Computed Tomography Scan
Undergo FDG-PET imaging
Lumbar Puncture
Undergo lumbar puncture
Multigated Acquisition Scan
Undergo MUGA
Tovorafenib
Given PO
RECRUITING
Sydney Children's Hospital, Randwick
RECRUITING
Queensland Children's Hospital, South Brisbane
RECRUITING
Perth Children's Hospital, Perth
RECRUITING
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
RECRUITING
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
NYP/Weill Cornell Medical Center, New York
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
New York Medical College, Valhalla
RECRUITING
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
RECRUITING
Maimonides Medical Center, Brooklyn
RECRUITING
Albany Medical Center, Albany
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Saint Christopher's Hospital for Children, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
West Virginia University Charleston Division, Charleston
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
RECRUITING
Duke University Medical Center, Durham
RECRUITING
East Carolina University, Greenville
RECRUITING
Mission Hospital, Asheville
RECRUITING
Prisma Health Richland Hospital, Columbia
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Memorial Health University Medical Center, Savannah
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
Arnold Palmer Hospital for Children, Orlando
RECRUITING
Nemours Children's Hospital, Orlando
RECRUITING
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
RECRUITING
Nicklaus Children's Hospital, Miami
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
RECRUITING
Children's Hospital of Alabama, Birmingham
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
East Tennessee Childrens Hospital, Knoxville
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
Rainbow Babies and Childrens Hospital, Cleveland
RECRUITING
Dayton Children's Hospital, Dayton
RECRUITING
Riley Hospital for Children, Indianapolis
SUSPENDED
Michigan State University, East Lansing
RECRUITING
Bronson Methodist Hospital, Kalamazoo
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
Blank Children's Hospital, Des Moines
RECRUITING
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
RECRUITING
Children's Hospital of Wisconsin, Milwaukee
RECRUITING
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
RECRUITING
University of Minnesota/Masonic Cancer Center, Minneapolis
RECRUITING
Lurie Children's Hospital-Chicago, Chicago
RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Saint Jude Midwest Affiliate, Peoria
RECRUITING
Cardinal Glennon Children's Medical Center, St Louis
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Children's Hospital New Orleans, New Orleans
RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Scott and White Memorial Hospital, Temple
RECRUITING
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
RECRUITING
M D Anderson Cancer Center, Houston
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
RECRUITING
Primary Children's Hospital, Salt Lake City
RECRUITING
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
RECRUITING
Summerlin Hospital Medical Center, Las Vegas
RECRUITING
Children's Hospital Los Angeles, Los Angeles
RECRUITING
Kaiser Permanente Downey Medical Center, Downey
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Children's Hospital of Orange County, Orange
RECRUITING
Valley Children's Hospital, Madera
RECRUITING
UCSF Medical Center-Mission Bay, San Francisco
RECRUITING
Lucile Packard Children's Hospital Stanford University, Palo Alto
RECRUITING
UCSF Benioff Children's Hospital Oakland, Oakland
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Connecticut Children's Medical Center, Hartford
RECRUITING
Yale University, New Haven
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
University of Alberta Hospital, Edmonton
RECRUITING
IWK Health Centre, Halifax
RECRUITING
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
RECRUITING
Children's Hospital, London
RECRUITING
Hospital for Sick Children, Toronto
RECRUITING
Centre Hospitalier Universitaire Sainte-Justine, Montreal
RECRUITING
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
RECRUITING
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
National Cancer Institute (NCI)
NIH