Prone Positioning and Abdominal Binding on Lung and Muscle Protection in ARDS Patients During Spontaneous Breathing

NARecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

December 6, 2023

Primary Completion Date

March 31, 2026

Study Completion Date

April 30, 2026

Conditions
Acute Respiratory Distress SyndromeMechanical Ventilation ComplicationICU Acquired Weakness
Interventions
PROCEDURE

Prone Positioning

Prone positioning will be performed according to ICU local protocol with trained provider teams.

PROCEDURE

Thoracoabdominal Binding

Thoracoabdominal binding will be used in semi-recumbent position (supine at 45º) and titrated to obtain a 20-30% decrease in chest wall compliance and 1-3 cm H2O increase in end-expiratory gastric pressure during steady-state breathing

PROCEDURE

Control

ARDS patients at spontaneous breathing onset on pressure support ventilation mode in supine position at 45º degrees, performed under standard PEEP according to ARDSNet strategy and individualized PEEP applied in random order.

Trial Locations (1)

Unknown

RECRUITING

Hospital Clínico Universidad de Chile, Independencia

All Listed Sponsors
collaborator

Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

OTHER_GOV

lead

University of Chile

OTHER