Continuous vs. Intermittent Infusion Vancomycin

PHASE4RecruitingINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

May 22, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Vancomycin
Interventions
DRUG

Vancomycin Continuous Infusion

A precision drug dosing platform will be used to determine the empiric dosing regimen and the dosing parameter targeted will be an area-under-the-curve (AUC) of 500 mg⸱hr/L (range 400-600 mg⸱hr/L). The total daily dose is infused over a period of 24 hours.

DRUG

Vancomycin Intermittent Infusion

A precision drug dosing platform will be used to determine the empiric dosing regimen and the dosing parameter targeted will be an area-under-the-curve (AUC) of 500 mg⸱hr/L (range 400-600 mg⸱hr/L). The dose is infused at rates of 1 gram per hour in every 8, -12, or -24 hour intervals.

Trial Locations (1)

40506

RECRUITING

University of Kentucky, Lexington

All Listed Sponsors
collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

lead

Aaron Cook

OTHER