285
Participants
Start Date
July 6, 2023
Primary Completion Date
June 21, 2025
Study Completion Date
August 11, 2025
abatacept infusion
The dose of abatacept will be 10 mg/kg given as a single infusion on Day 0, with a maximum dose of 1,750 mg, so any participant with weight of \>175 kg will receive a dose of 1750 mg. + baseline IM (immune modulator)
Placebo group
Placebo group (IV infusion of normal saline) + baseline IM
St. Vincent's Hospital (Site 612-002), Sydney
Rigshospitalet, CHIP (Site 625-006), Copenhagen
Westmead Hospital (Site 612-058), Westmead
Bispebjerg Hospital (Site 625-013), Copenhagen
Hvidovre University Hospital, Department of Infectious Diseases (Site 625-001), Hvidovre
Herlev/Gentofte Hospital (Site 625-012, Hellerup
The Alfred Hospital (612-017), Melbourne
Austin Health (612-020), Heidelberg
Monash Health (612-009), Clayton
Nordsjællands Hospital, Hillerød (Site 625-009), Hillerød
Royal Brisbane and Women's Hospital (612-055), Brisbane
University Hospital Basel (636-004), Basel
Odense University Hospital (625-004), Odense
Aarhus Universitetshospital, Skejby (Site 625-002), Aarhus
Aalborg Hospital (Site 625-005), Aalborg
Hospital #1 of Zhytomyr City Council (627-303), Zhytomyr
New York University Langone Health (301-013), New York
NYC Health + Hospital Harlem (Site 003-003), New York
Weill Cornell Clinical Research Unit (065-001), New York
Chulalongkorn University and The HIV-NAT (Site 613-001), Bangkok
Lincoln Medical Center (Site 003-016), The Bronx
James J. Peters VAMC (Site 023-003), The Bronx
Siriraj Hospital (613-002), Bangkok Noi
NYU Brooklyn (301-033), Brooklyn
Mount Sinai Medical Center (Site 301-012), New York
New York Presbyterian Queens (003-005), Flushing
NYU Long Island (301-034), Mineola
1st Respiratory Medicine Department, Athens University Medical School (635-015), Athens
3rd Dept of Medicine, Medical School, NKUA (635-022), Athens
Attikon University General Hospital (Site 635-009), Athens
Seoul National University Bundang Hospital (612-904), Seongnam
Penn State Health Milton S. Hershey Medical Center (Site 209-002), Hershey
MedStar Health Research Institute (Site 009-021), Washington D.C.
Washington DC VA Medical Center (Site 009-004), Washington D.C.
Salem VA Medical Center (Site 074-014), Salem
West Virginia University Medicine (Site 301-023), Morgantown
Wake Forest Baptist Health (Site 210-001), Winston-Salem
Duke University Hospital (Site 301-006), Durham
Hospital Universitario La Paz (Site 626-012), Madrid
Ralph H. Johnson VA Medical Center (074-015), Charleston
Medical University of South Carolina (Site 210-002), Charleston
Hope Clinic, Emory University (Site 301-031), Decatur
Emory Grady (Site 301-032), Atlanta
Hôpital Saint André (Site 631-041), Bordeaux
Tampa General Hospital (032-001), Tampa
University of Alabama Birmingham University Hospital (Site 213-002), Birmingham
Vanderbilt University Medical Center (Site 212-001), Nashville
University of Mississippi Medical Center (Site 202-005), Jackson
Khon Kaen University, Srinagarind Hospital (613-003), Khon Kaen
Cleveland Clinic Foundation (Site 207-001), Cleveland
Lutheran Medical Group (301-010), Fort Wayne
VA Ann Arbor Healthcare System (Site 074-028), Ann Arbor
University of Michigan Medical Center (205-001), Ann Arbor
Henry Ford Health System (014-001), Detroit
Sinai-Grace Hospital (Site 205-005), Detroit
Klinik I für Innere Medizin der Universität zu Köln (622-008), Cologne
Froedtert Memorial Lutheran Hospital (052-001), Milwaukee
William S. Middleton Memorial Veterans Hospital (074-030), Madison
M Health Fairview University of Minnesota Medical Center (112-001), Minneapolis
University of Minnesota, Minneapolis
University of Illinois at Chicago (008-012), Chicago
Washington University School of Medicine (Site 003-001), St Louis
University of Kansas Medical Center (Site 080-044), Kansas City
Democritus University of Thrace (635-021), Alexandroupoli
University of Nebraska Medical Center (Site 080-045), Omaha
Parkland Health and Hospital Systems (084-002), Dallas
Baylor, Scott and White Health (301-003), Dallas
UT Southwestern Medical Center (084-001), Dallas
Central City Clinical Hospital of Ivano-Frankivsk City Council (627-302), Ivano-Frankivsk
Houston Methodist Research Institute (Site 301-028), Houston
University of Texas Health Science Center (Site 203-006), Houston
UT Health San Antonio (Site 009-022), San Antonio
CHRISTUS Spohn Shoreline Hospital (080-001), Corpus Christi
Hendrick Medical Center (Site 080-014), Abilene
Rocky Mountain Regional VA Medical Center (Site 074-010), Aurora
University of Colorado Hospital (Site 204-001), Aurora
Public Health Institute at Denver Health (Site 017-004), Denver
Intermountain Medical Center (Site 211-001), Murray
University of Utah Hospital (211-002), Salt Lake City
Banner University Medical Center Tucson (Site 206-004), Tucson
Southern Arizona VA Healthcare System (Site 074-009), Tucson
University of New Mexico Hospital (Site 213-008), Albuquerque
Cedars-Sinai Medical Center (208-002), Los Angeles
Ronald Reagan UCLA Medical Center (Site 203-002), Los Angeles
MemorialCare Health System (066-003), Long Beach
VA Long Beach Healthcare System (074-026), Long Beach
VA San Diego Healthcare System (074-016), San Diego
VA Loma Linda Healthcare System (074-017), Loma Linda
UCSF Fresno (Site 203-005), Fresno
Zuckerberg San Francisco General Hospital and Trauma Center (213-007), San Francisco
UCSF Medical Center at Mount Zion (203-007), San Francisco
San Francisco VAMC (Site 074-002), San Francisco
UCSF Medical Center (Site 203-001), San Francisco
Stanford University Hospital & Clinics (Site 203-003), Stanford
UC Davis Health (Site 203-004), Davis
VA Northern California Health Care System (Site 074-023), Mather
Oregon Health and Science University (208-003), Portland
Harborview Medical Center (208-001), Seattle
Providence (Sacred Heart) (213-004), Spokane
Tan Tock Seng Hospital (Site 612-201), Singapore
Chennai Antiviral Research and Treatment Clinical Research Site (Site 612-402), Chennai
Yale University (Site 025-001), New Haven
Massachusetts General Hospital (202-002), Boston
Beth Israel Deaconess Medical Center (202-001), Boston
Lahey Hospital and Medical Center (Site 213-001), Burlington
Baystate Medical Center (Site 201-001), Springfield
University of Massachusetts Chan Medical School (080-007), Worcester
Dartmouth-Hitchcock Medical Center (301-024), Lebanon
Cooper University Hospital (019-001), Camden
New Jersey Medical School Clinical Research Center (028-001), Newark
Rhode Island Hospital (Site 080-036), Providence
The Miriam Hospital (Site 080-039), Providence
AIDS and Clinical Immunology Research Center (627-201), Tbilisi
St Vincent's University Hospital (Site 634-103), Dublin
Institute of Human Virology-Nigeria (IHVN) (612-601), Abuja
Wojewodzki Szpital Zakazny (Site 625-302), Warsaw
National Medical Center (612-905), Seoul
Asan Medical Center (612-901), Seoul
Seoul St. Mary's Hospital (Site 612-903), Seoul
Chung-Ang University Hospital (612-902), Seoul
Hospital Universitari Germans Trias i Pujol (626-003), Badalona
Hospital del Mar (626-025), Barcelona
Hospital Universitari Vall d'Hebron (626-033), Barcelona
Hospital Clinic de Barcelona (626-004), Barcelona
Karolinska University Hospital, Solna (Site 625-206), Stockholm
Treatment and Diagnostic Center ADONIS Plus (627-304), Kyiv
University Hospital Plymouth NHS Trust (Site 634-014), Plymouth
University of Minnesota
OTHER