Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

June 7, 2023

Primary Completion Date

April 30, 2028

Study Completion Date

December 31, 2028

Conditions
Large B-cell LymphomaDiffuse Large B Cell Lymphoma
Interventions
DRUG

R-miniCHOP + Acalabrutinib

"* Rituximab i.v.: 375 mg/m2 (D0)~* Cyclophosphamide i.v.: 400 mg/m² (D1)~* Doxorubicin i.v.: 25 mg/m² (D1)~* Vincristine i.v.: 1 mg (D1)~* Prednisolone p.o.: 40 mg/m² (D1 to D5)~* Acalabrutinib 100 mg p.o. twice daily starting from D1 of first R-miniCHOP cycle continuously to D21 of cycle 8.~Cycles repeated every 3 weeks"

DRUG

R-miniCHOP

"* Rituximab i.v.: 375 mg/m2 (D0)~* Cyclophosphamide i.v.: 400 mg/m² (D1)~* Doxorubicin i.v.: 25 mg/m² (D1)~* Vincristine i.v.: 1 mg (D1)~* Prednisolone p.o.: 40 mg/m² (D1 to D5).~Cycles repeated every 3 weeks"

Trial Locations (17)

66421

RECRUITING

Saarland University Medical Center, Homburg

Unknown

NOT_YET_RECRUITING

MVZ am Klinikum Aschaffenburg, Aschaffenburg

RECRUITING

Helios Klinikum Emil von Behring, Berlin

NOT_YET_RECRUITING

Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin

NOT_YET_RECRUITING

Gemeinschaftspraxis Mohm/Prange-Krex, Dresden

RECRUITING

Universitätsklinikum Gießen und Marburg, Standort Gießen, Giessen

RECRUITING

Universitätsmedizin Greifswald, Greifswald

RECRUITING

Universitätsmedizin Halle (Saale), Halle

RECRUITING

Städtisches Klinikum Karlsruhe, Karlsruhe

NOT_YET_RECRUITING

Johannes Wesling Klinikum, Minden

NOT_YET_RECRUITING

Rheinland Klinikum-Lukaskrankenhaus Neuss, Neuss

NOT_YET_RECRUITING

Brüderkrankenhaus St. Josef, Paderborn

RECRUITING

CaritasKlinikum Saarbrücken St. Theresia, Saarbrücken

RECRUITING

Klinikum Mutterhaus der Borromäerinnen, Trier

NOT_YET_RECRUITING

Krankenhaus der Barmherzigen Brüder Trier, Trier

NOT_YET_RECRUITING

Bundeswehrkrankenhaus Ulm, Ulm

RECRUITING

Universitätsklinikum Ulm, Ulm

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Leipzig

OTHER

collaborator

University Hospital Regensburg

OTHER

collaborator

Wuerzburg University Hospital

OTHER

collaborator

University Hospital of Gießen and Marburg

UNKNOWN

collaborator

Saarland University Medical Center

UNKNOWN

collaborator

AstraZeneca

INDUSTRY

lead

Universität des Saarlandes

OTHER