NCT05820711View on ClinicalTrials.gov

Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 17, 2023

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Head and Neck CancerXerostomia
Interventions
DRUG

MSC

"Injection of MSCs into submandibular glands at pre-specified dose level:~* Dose -1: 5 (4 - 6) x10\^6 MSCs (to be used only if Dose level 1 is not tolerated) per gland (0.5 ml)~* Dose 0: 10 (8 - 12) x10\^6 MSCs per gland (1 ml)~* Dose 1: 20 (16 - 24) x10\^6 MSCs per gland (2 ml)"

Trial Locations (1)

53705

RECRUITING

University of Wisconsin Carbone Cancer Center, Madison

All Listed Sponsors
collaborator

National Institute of Dental and Craniofacial Research (NIDCR)

NIH

lead

University of Wisconsin, Madison

OTHER