ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks

RecruitingOBSERVATIONAL
Enrollment

45

Participants

Timeline

Start Date

July 28, 2023

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Metabolic Health
Interventions
OTHER

Whole Room Calorimeter

The indirect calorimetry system allows your oxygen / carbon dioxide exchange to be measured, thereby showing the number of calories burned.

OTHER

Mixed-Meal Tolerance Test (MMTT)

The MMTT is done to measure how much body handles a mixed meal.This test shake will raise blood sugar and cause the body to produce insulin.

OTHER

Core Body Temperature

Participants will be asked to swallow a core body temperature monitor prior to entering the whole room calorimeter. This monitor is used to record participants core body temperature.

OTHER

Morningness-Eveningness Questionnaire

Participants will fill out a questionnaire that asks about your preference for morning or evening.

PROCEDURE

Muscle Biopsy

Participants will have two skeletal muscle biopsies (one in the evening and one in the morning). This procedure is used to sample muscle cells from the right and left leg Vastus Lateralis (thigh) muscle.

OTHER

Serial Blood Sampling

Participants will have blood sampled every hour for 24 hours to assess changes in circulating hormones.

Trial Locations (1)

32804

RECRUITING

AdventHealth Translational Research Institute, Orlando

All Listed Sponsors
lead

AdventHealth Translational Research Institute

OTHER