Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock.

PHASE2RecruitingINTERVENTIONAL
Enrollment

234

Participants

Timeline

Start Date

December 27, 2023

Primary Completion Date

December 30, 2025

Study Completion Date

January 24, 2026

Conditions
Cardiac Arrest
Interventions
DRUG

Vitamin C (Laroscorbine) + Vitamin B1 (Bevitine)

in addition of standard post-CA as the control group, patients will receive an IV high-dose vit-C 50mg/kg infusion every 6 hours, started within the hour after randomization, for 3 days. In addition, all patients will receive intravenous thiamine 200 mg twice a day for 3 days to limit the oxalate production.

DRUG

standard treatment

no intervention Standard IV vit-C supplementation will be allowed for dosages up to 1000 mg a day from day 4 after randomization, as well as thiamin supplementation.

Trial Locations (10)

62307

NOT_YET_RECRUITING

Centre Hospitalier de LENS, Lens

62408

ACTIVE_NOT_RECRUITING

Centre Hospitalier Béthune, Béthune

75475

NOT_YET_RECRUITING

Hôpital Lariboisière, Paris

Unknown

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire d'Amiens, Amiens

RECRUITING

Centre Hospitalier de Dieppe, Dieppe

RECRUITING

GHEF Site Marne La Vallée, Jossigny

RECRUITING

Centre Hospitalier Universitaire de LILLE, Lille

ACTIVE_NOT_RECRUITING

Centre Hospitalier de Rouen, Rouen

RECRUITING

Centre Hospitalier Toulon La Seyne sur Mer, Toulon

ACTIVE_NOT_RECRUITING

Centre Hospitalier de Valenciennes, Valenciennes

All Listed Sponsors
collaborator

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

OTHER

collaborator

University Hospital, Lille

OTHER

lead

Centre Hospitalier de Bethune

NETWORK