A Study of SKB264 (MK-2870; Sac-TMT) for the Treatment of Participants With Advanced or Metastatic Non-small Cell Lung Cancer (SKB264-II-04) (MK-2870-003)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

356

Participants

Timeline

Start Date

April 19, 2023

Primary Completion Date

December 1, 2025

Study Completion Date

October 30, 2026

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

SKB264

intravenous (IV) infusion (Q2W or Q3W)

DRUG

Pembrolizumab

intravenous (IV) infusion (400mg, Q6W)

DRUG

Carboplatin

intravenous (IV) infusion (AUC5, Q3W)

DRUG

Osimertinib

80mg, QD

Trial Locations (60)

6351

Samsung Medical Center, Seoul

13620

Seoul National University Bundang Hospital, Seongnam-si

16247

The Catholic University of Korea, St. Vincent's Hospital, Suwon

28222

Hospital Universitario Puerta De Hierro De Majadahonda, Majadahonda

28223

Hospital Universitario QuirónSalud Madrid, Pozuelo de Alarcón

28644

Chungbuk National University Hospital, Cheongju-si

29004

Hospital Quironsalud Malaga, Málaga

30009

Shanxi Provincial Cancer Hospital, Taiyuan

41014

Hospital Universitario Virgen de Valme, Seville

44280

Inonu University Turgut Ozal Medical Center, Malatya

45008

Henan Cancer Hospital,Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou

46010

Hospital Clinico Universitario De Valencia, Valencia

48108

Inje University Haeundae Paik Hospital, Busan

100142

Beijing Cancer Hospital, Beijing

110002

The First Hospital of Chinese Medical University(Heping Compus), Shenyang

130021

Jilin Cancer Hospital, Changchun

The First Hospital of Jilin University, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

200030

Shanghai Chest Hospital, Shanghai

200032

Fudan University Shanghai Cancer Center, Shanghai

200123

Shanghai East Hospital, Shanghai

200542

Centrul de Oncologie Sf. Nectarie, Craiova

250117

Shandong Cancer Hospital and Institute, Jinan

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

310003

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

330029

Jiangxi Cancer Hospital, Nanchang

350014

Fujian Cancer Hospital, Fuzhou

400000

Chongqing University Cancer Hospital (Chongqing Cancer Hospital), Chongqing

400015

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Cluj-Napoca

400641

Medisprof, Cluj-Napoca

410013

Hunan Cancer Hospital, Changsha

430022

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

430071

Zhongnan Hospital of Wuhan University, Wuhan

430079

Hubei Cancer Hospital, Wuhan

450052

The First Affiliated Hospital of Zhengzhou University(Heyi Compus), Zhengzhou

510060

Sun Yat-Sen University Cancer Center, Guangzhou

510700

Sun Yatsen University Cancer Center Huangpu Hos, Guangzhou

530021

Guangxi Cancer Hospital/ Guangxi Medical University Cancer Hospital, Nanning

610041

Sichuan Cancer Hospital, Chengdu

West China Hospital of Sichuan University, Chengdu

611130

Chengdu Fifth People's Hospital, Chengdu

650118

Yunnan Cancer Hospital,The Third Affiliated Hospital of Kunming Medical University ,Yunnan Cancer Center, Kunming

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

0112

ISR-GEO Med Res Clin Healthycore, Tbilisi

"LLC Todua Clinic", Tbilisi

0114

Ltd New Hospitals, Tbilisi

0144

Tbilisi St Med U Ingorokva High Med, Tbilisi

0159

LTD Institute of Clinical Oncology, Tbilisi

03722

Severance Hospital, Yonsei University Health System, Seoul

08017

Micancer Center S.L.P., Barcelona

08028

Hospital Universitari Dexeus Grupo Quironsalud, Barcelona

08035

Hospital Universitari Vall D Hebron, Barcelona

01140

Medical Park Seyhan Hospital, Adana

01370

Adana City Training and Research Hospital, Adana

06010

Gulhane Egitim ve Arastirma Hastanesi Tibbi Onkoloji Klinigi, Ankara

06230

Hacettepe University Medical Faculty, Ankara

06500

Gazi University Medical Faculty, Ankara

06680

Ankara Liv Hospital Tibbi Onkoloji, Ankara

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

INDUSTRY

lead

Klus Pharma Inc.

INDUSTRY