Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

May 23, 2025

Primary Completion Date

July 15, 2027

Study Completion Date

March 30, 2030

Conditions
Oligometastatic Squamous Cell Carcinoma of the Head and Neck
Interventions
DRUG

Pembrolizumab

Pembrolizumab: 400mg Q6W up to 2 years (i.e 17 cycles).

RADIATION

stereotattic ablation radiotherapy (SABR)

Total dose and number of fractions will depend on the site of the disease. Three-fraction regimens will deliver a fraction every second day, and five-fraction regimens are delivered daily. All treatments have to be completed within 10 working days.

Trial Locations (26)

1200

NOT_YET_RECRUITING

Cliniques Universitaires Saint-Luc, Brussels

2610

NOT_YET_RECRUITING

Ziekenhuis aan de Stroom (ZAS) - ZAS Augustinus (previous GZA), Wilrijk

3010

NOT_YET_RECRUITING

Inselspital - Inselspital, Bern

5000

NOT_YET_RECRUITING

CHU-UCL Namur - CHU Site Sainte-Elisabeth-UCL Namur, Namur

5001

NOT_YET_RECRUITING

Kantonsspital Aarau, Aarau

6004

NOT_YET_RECRUITING

Luzerner Kantonsspital, Lucerne

6500

NOT_YET_RECRUITING

Oncology Institute of Southern Switzerland (IOSI) - Oncology Institute of Southern Switzerland - Ospedale San Giovanni, Bellinzona

7000

NOT_YET_RECRUITING

Kantonsspital Graubuenden, Chur

8401

NOT_YET_RECRUITING

Kantonsspital Winterthur, Winterthur

8500

NOT_YET_RECRUITING

AZ Groeninge Kortrijk - Campus Kennedylaan, Kortrijk

8901

NOT_YET_RECRUITING

UniversitaetsSpital Zurich, Zurich

9100

NOT_YET_RECRUITING

VITAZ St Niklaas - VITAZ- Oncology, Sint-Niklaas

20089

NOT_YET_RECRUITING

Istituto Clinico Humanitas, Milan

20133

NOT_YET_RECRUITING

IRCCS - Fondazione Istituto Nazionale dei Tumori, Milan

28034

NOT_YET_RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

28040

NOT_YET_RECRUITING

Hospital Universitario San Carlos, Madrid

35010

NOT_YET_RECRUITING

Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria

40139

NOT_YET_RECRUITING

IRCCS--Ospedale Bellaria-Bologna, Bologna

48018

NOT_YET_RECRUITING

AUSL - Ospedale Infermi, Faenza

48022

NOT_YET_RECRUITING

AUSL -Ospedale Umberto I, Lugo

48121

NOT_YET_RECRUITING

AUSL Romagna - AUSL Della Romagna -Ospedale Santa Maria delle Croci, Ravenna

50134

NOT_YET_RECRUITING

Univ. of Florence -Azienda Ospedaliero-Universitaria Careggi, Florence

80147

NOT_YET_RECRUITING

Azienda Sanitaria Locale Napoli 1 Centro, Napoli

00161

NOT_YET_RECRUITING

Azienda ospedaliero Univ Policlinico Umberto I, Rome

08035

RECRUITING

Hospital Universitari Vall d'Hebron -Vall d'Hebron Institut Oncologia, Barcelona

08908

NOT_YET_RECRUITING

ICO L'Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia), Barcelona

All Listed Sponsors
collaborator

Swiss Cancer Institute

OTHER

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK