Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

487

Participants

Timeline

Start Date

June 15, 2023

Primary Completion Date

August 31, 2025

Study Completion Date

August 31, 2026

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Upadacitinib

Oral Tablets

DRUG

Adalimumab

Subcutaneous Injection

DRUG

Upadacitinib Matching Placebo

Oral Tablets

DRUG

Adalimumab Matching Placebo

Subcutaneous Injection

Trial Locations (218)

1015

Organizacion Medica de Investigacion (OMI) /ID# 253253, Ciudad Autonoma de Buenos Aire

1023

Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 253311, Budapest

1428

Consultorios Reumatologicos Pampa /ID# 254095, Ciudad Autonoma de Buenos Aire

1463

Diagnostic consultative center Focus-5 /ID# 252354, Sofia

Diagnostic consultative center Focus-5 /ID# 252555, Sofia

1505

Diagnostic consultative center 17 Sofia /ID# 252341, Sofia

1606

Military Medical Academy Multiprofile Hospital /ID# 252355, Sofia

1958

Aprillus Asistencia e Investigacion /ID# 253258, Ciudad Autonoma de Buenos Aire

3600

ReumaClinic /ID# 252277, Genk

4000

Centro de Investigaciones Medicas Tucuman /ID# 253297, San Miguel de Tucumán

CIMER Centro Integral de Medicina Respiratoria /ID# 255277, San Miguel de Tucumán

CHU de Liege /ID# 252309, Liège

4001

Umbal Kaspela /ID# 252343, Plovdiv

4023

Medical center Unimed /ID# 252344, Plovdiv

4027

MHAT Plovdiv /ID# 252342, Plovdiv

4319

Dr Asokan Naidoo /ID# 252894, Umhlanga

5000

MÁV Kórház /ID# 252628, Szolnok

7130

Winelands Medical Research - Somerset West /ID# 252745, Cape Town

7405

Arthritis Clinical Research Trials /ID# 252370, Cape Town

7600

Winelands Medical Research Centre /ID# 252369, Stellenbosch

8000

AZ Sint-Jan Brugge /ID# 252278, Bruges

CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 252400, Székesfehérvár

8200

Vital Medicina Kft /ID# 252399, Veszprém

9000

UZ Gent /ID# 252306, Ghent

10000

Medical Center Kuna-Peric /ID# 252452, Zagreb

Poliklinika Bonifarm /ID# 252741, Zagreb

Poliklinika Repromed /ID# 252451, Zagreb

Poliklinika Solmed /ID# 252453, Zagreb

11000

Institute for Rheumatology /ID# 252333, Belgrade

Institute for Rheumatology /ID# 252334, Belgrade

Institute for Rheumatology /ID# 252335, Belgrade

Institute for Rheumatology /ID# 252338, Belgrade

11201

NYU Langone Ambulatory Care Brooklyn Heights /ID# 254621, Brooklyn

11527

General Hospital of Athens Laiko /ID# 252258, Athens

11850

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 252873, Mexico City

12462

University General Hospital Attikon /ID# 254751, Athens

15706

Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 252430, Santiago de Compostela

17268

Rheumatologische-Immunologische Praxis Templin /ID# 252863, Templin

19114

Clinical Research of Philadelphia, LLC /ID# 255025, Philadelphia

20060

Atlanta Research Center for Rheumatology /ID# 254623, Marietta

20095

MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 252667, Hamburg

20122

ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO /ID# 252461, Milan

21000

Special Hospital for Rheuma /ID# 252336, Novi Sad

Special Hospital for Rheuma /ID# 252339, Novi Sad

28204

Joint And Muscle Research Institute /ID# 275128, Charlotte

31000

Investigacion y Biomedicina de Chihuahua /ID# 253115, Chihuahua City

31059

CHU Toulouse - Hopital Purpan /ID# 252402, Toulouse

31151

SoonChunHyang University Hospital Cheonan /ID# 254942, Cheonan-si

32117

International Medical Research /ID# 254651, Daytona Beach

32174

Millennium Research /ID# 253744, Ormond Beach

32819

HMD Research LLC /ID# 253732, Orlando

33014

Lakes Research, LLC /ID# 255023, Miami

33024

Gnp Research - Hollywood /ID# 273563, Hollywood

33063

Life Clinical Trials /ID# 256061, Margate

33065

Believe Clinical Trial /ID# 262355, Coral Springs

33180

Arthritis and Rheumatic Disease Specialties /ID# 260583, Aventura

33410

Vitalia Research /ID# 274213, Palm Beach Gardens

33486

Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 253733, Boca Raton

33511

Bay Area Arthritis and Osteo /ID# 254046, Brandon

33606

Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 254649, Tampa

Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 255264, Tampa

33613

University of South Florida- Neuroscience Institute /ID# 253745, Tampa

33614

Baycare Medical Group - Tampa /ID# 255268, Tampa

33705

BayCare Medical Group /ID# 253799, St. Petersburg

34090

CHU Montpellier - Hôpital Lapeyronie /ID# 252386, Montpellier

35015

Chungnam National University Hospital /ID# 252159, Daejeon

38305

West Tennessee Research Institute /ID# 254620, Jackson

39402

Arthritis Associates /ID# 253992, Hattiesburg

40504

Bluegrass Community Research /ID# 254653, Lexington

40882

Rheumazentrum Ratingen /ID# 252669, Ratingen

42240

Western KY Rheumatology /ID# 255026, Hopkinsville

44130

Paramount Medical Research and Consulting /ID# 254048, Middleburg Heights

44160

Centro Integral en Reumatologia S.A de C.V /ID# 252872, Guadalajara

44649

Rheumazentrum Ruhrgebiet /ID# 252670, Herne

44650

Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 253480, Guadalajara

45067

Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 252385, Orléans

46026

Hospital Universitario y Politecnico La Fe /ID# 254143, Valencia

48439

AA Medical Research Center - Grand Blanc /ID# 254007, Grand Blanc

48910

Advanced Rheumatology, PC /ID# 256059, Okemos

49217

Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice /ID# 252455, Krapinske Toplice

50134

Azienda Ospedaliero Universitaria Careggi /ID# 252460, Florence

53132

Aurora Rheumatology and Immunotherapy Center /ID# 254049, Franklin

53217

Rheumatic Disease Center, LLP /ID# 254015, Glendale

55121

St. Paul Rheumatology, PA /ID# 255037, Eagan

58701

Trinity Health Med Arts Clinic /ID# 254010, Minot

59901

Logan Health Research - Glacier View Research Institute - Rheumatology /ID# 253738, Kalispell

60020

Azienda Ospedaliero Universitaria delle Marche /ID# 252459, Ancona

60048

Deerbrook Medical Associates /ID# 254008, Libertyville

60076

Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 253999, Skokie

60527

Willow Rheumatology and Wellness, PLLC /ID# 254712, Willowbrook

60616

Next Innovative Clinical Research - Chicago /ID# 273453, Chicago

61748

Chonnam National University Bitgoeul Hospital /ID# 254802, Gwangju

64151

Kansas City Physician Partners /ID# 255035, Kansas City

65807

Clinvest Research LLC /ID# 254054, Springfield

68516

Physician Research Collaboration, LLC /ID# 254012, Lincoln

70121

Ochsner Clinic Foundation /ID# 254059, New Orleans

71203

The Arthritis & Diabetes Clinic, Inc. /ID# 254014, Monroe

71500

University General Hospital of Heraklion PA.G.N.I /ID# 252261, Heraklion

75007

Trinity Universal Research Associates - Carrollton /ID# 254648, Carrollton

76000

Hôpital Charles-Nicolle /ID# 252908, Rouen

77043

Biopharma Informatic - Houston - Business Center Drive /ID# 254051, Houston

Biopharma Informatic - Houston - Business Center Drive /ID# 254053, Houston

77375

DM Clinical Research - Tomball /ID# 254001, Tomball

77377

Rheumatology Clinic of Houston /ID# 254002, Tomball

77382

Advanced Rheumatology of Houston /ID# 254003, The Woodlands

78215

Sun Research Institute /ID# 255019, San Antonio

78404

Adriana Pop-Moody MD Clinic PA /ID# 255030, Corpus Christi

78745

Tekton Research, L.L.C /ID# 254004, Austin

79424

West Texas Clinical Research /ID# 253736, Lubbock

80002

Centro Integral de Reumatología del Caribe SAS - Circaribe SAS /ID# 252587, Barranquilla

80045

University of Colorado Hospital /ID# 254617, Aurora

80054

CHU Amiens-Picardie Site Sud /ID# 252384, Amiens

80230

Denver Arthritis Clinic /ID# 254058, Denver

80528

Tekton Research - Fort Collins - East Harmony Road /ID# 255036, Fort Collins

82152

Klinische Forschung im med. Versorgungsalltag GbR /ID# 254221, Planegg

85032

Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 253432, Phoenix

Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 255021, Phoenix

85381

Sun Valley Arthritis Center Ltd. /ID# 254654, Peoria

85704

Arizona Arthritis & Rheumatology Associates - Tucson /ID# 255017, Tucson

88011

Arthritis and Osteoporosis Associates of New Mexico /ID# 252684, Las Cruces

90502

The Lundquist Institute at Harbor-UCLA Medical Center /ID# 252691, Torrance

91364

Comprehensive Rheumatology Center /ID# 252688, Woodland Hills

91942

Purushotham & Akther Kotha MD, Inc /ID# 252704, La Mesa

92835

Providence - St. Jude Medical Center /ID# 252690, Fullerton

100034

Peking University First Hospital /ID# 252392, Beijing

100191

Peking University Third Hospital /ID# 252393, Beijing

110221

Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 252586, Bogotá

210008

Nanjing Drum Tower Hospital /ID# 252613, Nanjing

233004

The first affiliated hospital of bengbu medical college /ID# 252612, Bengbu

250252

Healthy Medical Center S.A.S /ID# 252585, Zipaquirá

300134

Cabinet Medical Dr. Avram S.R.L /ID# 254133, Timișoara

300766

Banat Carina Med SRL /ID# 252757, Timișoara

337055

Jiangxi Pingxiang People's Hospital /ID# 252381, Pingxiang

412007

Zhuzhou Central Hospital /ID# 252390, Zhuzhou

510630

The Third Affiliated Hospital, Sun Yat-Sen University /ID# 252394, Guangzhou

600114

Spitalul Judetean de Urgenta Bacau /ID# 252860, Bacau

610041

West China Hospital, Sichuan University /ID# 252364, Chengdu

681004

Fundacion Oftalmologica de Santander - FOSCAL /ID# 252589, Bucaramanga

1710216

Corporacion de Beneficiencia Osorno /ID# 252556, Osorno

7640881

Clinica Dermacross /ID# 252560, Vitacura

8207257

Complejo Asistencial Dr. Sotero del Rio /ID# 252559, Santiago

8420383

Centro Internacional de Estudios Clinicos - CIEC /ID# 252561, Santiago

8620975

Kumamoto Orthopaedic Hospital /ID# 253167, Kumamoto

86001-6299

AZ Arthritis and Rheumotology Research, PLLC - Flagstaff /ID# 253431, Flagstaff

85306-9802

Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 255018, Glendale

72401-6251

Arthritis and Rheumatism Associates /ID# 254013, Jonesboro

92648-5994

Newport Huntington Medical Group /ID# 252687, Huntington Beach

90720-5402

Valerius Medical Group & Research Center of Greater Long Beach, Inc /ID# 252692, Los Alamitos

92128-2549

Rheumatology Center of San Diego /ID# 255038, San Diego

91360-3951

Millennium Clinical Trials /ID# 252689, Thousand Oaks

32713-2260

Omega Research Debary, LLC /ID# 253735, DeBary

33016-1897

Neoclinical Research /ID# 254622, Hialeah

61114-4937

OrthoIllinois /ID# 254057, Rockford

60195-3106

Greater Chicago Specialty Physicians /ID# 254000, Schaumburg

47715-2813

Qualmedica Research - Evansville /ID# 254005, Evansville

04102-2643

Rheumatology Associates PA - Portland /ID# 255014, Portland

02149-4903

Beth Israel Deaconess Medical Center - Rheumatology /ID# 255029, Boston

03756

Dartmouth-Hitchcock Medical Center - 1 Medical Center Drive /ID# 253798, Lebanon

08043

Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 255266, Voorhees Township

73116-7226

Rheumatology Associates of Oklahoma /ID# 253994, Oklahoma City

75013-6147

Arthritis and Rheumatology Research Institute, PLLC /ID# 254045, Allen

76104-4917

JPS Rheumatology Clinic /ID# 254050, Fort Worth

77089-6142

Accurate Clinical Research - Houston /ID# 254647, Houston

77450-2244

R & H Clinical Research - 777 Katy /ID# 255024, Katy

75024-5283

Trinity Universal Research Associates, Inc /ID# 253995, Plano

36010-570

CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 254203, Juiz de Fora

80030-110

CETI - Centro de Estudos em Terapias Inovadoras /ID# 254201, Curitiba

90035-903

Hospital de Clinicas de Porto Alegre /ID# 254916, Porto Alegre

90480-000

LMK Sevicos Medicos S/S /ID# 254202, Porto Alegre

15090-000

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 254917, São José do Rio Preto

04266-010

CEPIC - Centro Paulista de Investigacao Clinica /ID# 254200, São Paulo

R3A 1M3

Manitoba Clinic /ID# 254019, Winnipeg

G5L 8W1

Centre Rhumatologie de l'Est /ID# 254932, Rimouski

G1V 3M7

Groupe de Recherche en Maladies Osseuses Inc /ID# 253409, Sainte-Foy

G8Z 1Y2

Centre de Recherche Musculo-Squelettique /ID# 256273, Trois-Rivières

S7H 0P4

Dr. Latha Naik Medical Professional Corporation /ID# 254018, Saskatoon

050034

Hospital Pablo Tobón Uribe /ID# 253371, Medellín

06001

Centre Hospitalier Universitaire de Nice Hopital Pasteur /ID# 254224, Nice

455-8530

Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 252836, Nagoya

457-8511

Daido Clinic - Nagoya /ID# 253058, Nagoya

277-8551

Kashiwa Kousei General Hospital /ID# 270033, Kashiwa-shi

910-0068

Sugimoto Rheumatology and Internal Medicine Clinic /ID# 252774, Fukui-shi

810-8539

Hamanomachi Hospital /ID# 253168, Fukuoka

814-0002

Shono Rheumatism Clinic /ID# 252591, Fukuoka

078-8243

Katayama Orthopedic Rheumatology Clinic /ID# 252746, Asahikawa-shi

060-0001

Sagawa Akira Rheumatology Clin /ID# 252773, Sapporo

063-0811

Hokkaido Medical Center For Rheumatic Diseases /ID# 270019, Sapporo

673-1462

Matsubara Mayflower Hospital /ID# 252834, Kato-shi

769-2393

Sanuki Municipal Hospital /ID# 252747, Sanuki-shi

781-0112

Bay Side Misato Medical Center /ID# 252661, Kochi

880-0053

Medical Corporation Keiai Kai Clinic /ID# 252750, Miyazaki

857-1195

Sasebo Chuo Hospital /ID# 252662, Sasebo-shi

598-0048

Rinku Hashimoto Rheumatology Orthopaedics /ID# 270396, Izumisano

104-8560

St.Luke's International Hospital /ID# 253131, Chuo-ku

160-8582

Keio University Hospital /ID# 253205, Shinjuku-ku

752-0976

Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 253057, Shimonoseki-shi

870-0823

Maeshima Rheumatology Clinic /ID# 270448, Ōita

930-0975

Toyama Prefectural Central Hospital /ID# 270871, Toyama

06090

Hospital de Jesus /ID# 253114, Mexico City

2805-267

Hospital Garcia de Orta /ID# 252491, Almada

4990-041

Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 252489, Ponte de Lima

1649-035

Unidade Local de Saude de Santa Maria, EPE /ID# 252492, Lisbon

00917-3104

GCM Medical Group PSC /ID# 252700, San Juan

00918-3756

Mindful Medical Research /ID# 252693, San Juan

011172

Spitalul Clinic Sf. Maria /ID# 252759, Bucharest

Spitalul Clinic Sf. Maria /ID# 253334, Bucharest

0001

University of Pretoria /ID# 252368, Pretoria

0002

Dr Elsa van Duuren /ID# 252387, Pretoria

Emmed Research cc /ID# 254317, Pretoria

03080

Seoul National University Hospital /ID# 252160, Seoul

04763

Hanyang University Seoul Hospital /ID# 252161, Seoul

03570

Hospital Marina Baixa /ID# 254141, Villajoyosa

08916

Hospital Universitario Germans Trias i Pujol /ID# 254144, Badalona

08208

Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 252425, Sabadell

NW3 2QG

Royal Free Hospital /ID# 252297, London

PE30 4ET

The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 252301, Kings Lynn

EC1M 6BQ

Queen Mary University of London /ID# 252671, London

PO6 3LY

Portsmouth Hospitals University NHS Trust /ID# 252772, Portsmouth

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY