NCT05812755View on ClinicalTrials.gov

SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery

PHASE4RecruitingINTERVENTIONAL
Enrollment

170

Participants

Timeline

Start Date

May 19, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

November 30, 2027

Conditions
Endothelial DysfunctionVascular DiseasesKidney InjuryBrain DiseaseVascular Inflammation
Interventions
DRUG

Vericiguat

Vericiguat 10 mg administered orally starting 2 days prior to heart surgery through the day of surgery

DRUG

Placebo

Matched placebo administered orally starting 2 days prior to heart surgery through the day of surgery

Trial Locations (1)

37204

RECRUITING

Vanderbilt University Medical Center, Nashville

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Vanderbilt University Medical Center

OTHER