Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa

PHASE3CompletedINTERVENTIONAL
Enrollment

1,732

Participants

Timeline

Start Date

July 12, 2023

Primary Completion Date

February 11, 2025

Study Completion Date

March 23, 2025

Conditions
Hemorrhage, PostpartumPlacenta Previa
Interventions
DRUG

Tranexamic acid

Intravenous administration of 10 mL (1 g of tranexamic acid), diluted in 40 ml of normal saline, over 10 minutes after umbilical-cord clamping, the routine prophylactic uterotonic administration

OTHER

0.9% sodium chloride

Intravenous administration of 10 mL placebo(0.9% sodium chloride), diluted in 40 ml of normal saline, over 10 minutes after umbilical-cord clamping, the routine prophylactic uterotonic administration

Trial Locations (27)

510150

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou

Unknown

Peking Union Medical College, Beijing

Peking University First Hospital, Beijing

Women and Children's Hospital of Chongqing Medical University, Chongqing

Dalian Women and Children's Medical Group, Dalian

Dongguan Maternal and Child Health Care Hospital, Dongguan

The Tenth Affiliated Hospital of Southern Medical University; Dongguan People's Hospital, Dongguan

Foshan Women and Children Hospital, Foshan

Boai Hospital of Zhongshan, Guangzhou

Huadu District People's Hospital of Guangzhou, Guangzhou

Nanfang Hospital, Southern Medical University, Guangzhou, Guangzhou

The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

The first Affiliated Hospital, Sun Yat-sen University, Guangzhou

The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou

Zhuhai Women and Children's Hospital, Guangzhou

Obstetrics Department, the Maternal and Child Health Hospital of Hunan Province, Hunan

Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan

Shenzhen Baoan Women's and Children's Hospital, Shenzhen

Shenzhen Maternal & Child Healthcare Hospital Affiliated Southern Medical University, Shenzhen

Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang

Tianjin Central Hospital of Gynecology Obsterics, Tianjin

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

Northwest Women's and Children's Hospital, Xi'an

First Affiliated Hospital of Xinjiang Medical University, Xinjiang

Urumqi Maternal and Child Health Care Hospital, Xinjiang

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

All Listed Sponsors
collaborator

Dongguan Maternal and Child Health Care Hospital

UNKNOWN

collaborator

Foshan Women's and Children's Hospital

OTHER

collaborator

BoAi Hospital of Zhongshan

OTHER

collaborator

Women and Children's Hospital of Chongqing Medical University

UNKNOWN

collaborator

Tianjin Central Hospital of Gynecology Obstetrics

OTHER

collaborator

Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan

UNKNOWN

collaborator

Urumqi Maternal and Child Health Care Hospital

UNKNOWN

collaborator

Zhuhai Women and Children's Hospital

UNKNOWN

collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

Hunan Provincial Maternal and Child Health Care Hospital

OTHER

collaborator

Dalian women and children's medical group

UNKNOWN

collaborator

Nanfang Hospital, Southern Medical University

OTHER

collaborator

Huadu District People's Hospital of Guangzhou

OTHER

collaborator

Northwest Women's and Children's Hospital, Xi'an, Shaanxi

OTHER

collaborator

First Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Shenzhen Maternity & Child Healthcare Hospital

OTHER

collaborator

Shenzhen Baoan Women's and Children's Hospital

UNKNOWN

collaborator

Dongguan People's Hospital

OTHER_GOV

collaborator

First Affiliated Hospital of Xinjiang Medical University

OTHER

collaborator

Tongji Hospital

OTHER

collaborator

Peking Union Medical College

OTHER

collaborator

Second Affiliated Hospital of Guangzhou Medical University

OTHER

collaborator

Fifth Affiliated Hospital of Guangzhou Medical University

OTHER

collaborator

Shijiazhuang Obstetrics and Gynecology Hospital

OTHER

lead

Guangzhou Medical University

OTHER