A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

305

Participants

Timeline

Start Date

March 6, 2023

Primary Completion Date

February 26, 2026

Study Completion Date

February 26, 2026

Conditions
Geographic Atrophy
Interventions
DRUG

JNJ-81201887

JNJ-81201887 will be administered as intravitreal injection.

DRUG

Prednisone

Prednisone will be administered as oral capsule.

OTHER

Placebo

Prednisone matching placebo will be administered as oral capsule.

DRUG

Triamcinolone

Triamcinolone (corticosteroid injection) periocular injection will be administered as per local practice.

OTHER

Sham Procedure

Sham injections matching to single JNJ-81201887 injection and matching to corticosteroid (triamcinolone) periocular injection will be administered.

Trial Locations (162)

1062

Eszak Pesti Centrumkorhaz Honvedkorhaz, Budapest

2000

Sydney Retina Clinic and Day Surgery, Sydney

2135

Strathfield Retina Clinic, Strathfield

2145

Sydney West Retina, Westmead

2600

University Hospital Of Copenhagen, Glostrup Hospital, Glostrup Municipality

3000

UZ Leuven Gasthuisberg, Leuven

3002

Centre for Eye Research Australia, East Melbourne

3010

Inselspital Universitatsspital Bern, Bern

3011

Het Oogziekenhuis Rotterdam, Rotterdam

3600

Ziekenhuis Oost-Limburg, Genk

4000

Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman, Liège

Zealand University Hospital, Roskilde

5000

Adelaide Eye and Retina Centre, Adelaide

7621

Ganglion Orvosi Központ, Pécs

8900

Zala Megyei Szent Rafael Korhaz, Zalaegerszeg

9000

UZ Gent, Ghent

Aalborg University Hospital, Aalborg

10022

Vitreous Retina Macula Consultants of New York, New York

11021

Long Island Vitreo Retinal Consultants, Great Neck

12159

Retina Consultants PLLC, Slingerlands

12180

Opthalmic Consultants of the Capital Region, Troy

12203

Charite Universitaetsmedizin Berlin, Berlin

13088

Retina-Vitreous Surgeons of Central New York, Liverpool

14012

Hosp. La Arruzafa, Córdoba

15000

AXON Clinical s.r.o., Prague

15706

Hosp. Prov. Do Conxo, Santiago de Compostela

16505

Erie Retina Research, Erie

20014

Hosp. Univ. Donostia, Donostia / San Sebastian

20122

Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano, Milan

20132

Ospedale San Raffaele, Milan

20157

Sacco Hospital, Milan

20815

The Retina Group of Washington, Chevy Chase

21204

Retina Specialists, Baltimore

21209

The Retina Care Center, Baltimore

21740

Cumberland Valley Retina Consultants, Hagerstown

23502

Wagner Kapoor Research institute, Norfolk

24105

Universitatsklinikum Schleswig Holstein Kiel, Kiel

24502

Piedmont Eye Center, Lynchburg

27587

NC Retina Associates, Wake Forest

28040

Hosp Univ Fund Jimenez Diaz, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

28046

Clinica Baviera Madrid Castellana, Madrid

28222

Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda

28602

Graystone Eye, Hickory

28803

Asheville Eye Associates - Western Carolina Retinal Associates, Asheville

29902

Charleston Neuroscience Institute, LLC, Beaufort

30060

Georgia Retina, Marietta

Marietta Eye Clinic, Marietta

30625

Medizinische Hochschule Hannover, Hanover

31008

Clinica Univ. de Navarra, Pamplona

32503

Retina Specialty Institute, Pensacola

32607

VitreoRetinal Associates, PA, Gainesville

33143

MedEye Associates, Miami

33308

Retina Group of Florida, Fort Lauderdale

33324

Fort Lauderdale Eye Institute, Plantation

33711

Retina Vitreous Associates of Florida, St. Petersburg

33912

National Opthalmic Research Institute, Fort Myers

34994

East Florida Eye Institute, Stuart

35330

Dokuz Eylul University Hospital, Izmir

35392

Universitatsklinikum Gießen - Klinik und Poliklinik fur Augenheilkunde, Giessen

37075

Klinikum Gottingen der Georg August Universitat, Göttingen

38138

Charles Retina Institute, Germantown

41013

Hosp. Virgen Del Rocio, Seville

42250

Konya Selcuk University Medical Faculty, Konya

44124

Arcispedale S. Anna Ferrara, Ferrara

44195

Cleveland Clinic, Cleveland

45242

Cincinnati Eye Institute, Cincinnati

46032

Midwest Eye Institute, Carmel

46100

Clinica Oftalvist Valencia, Burjassot

48073

Associated Retinal Consultants P.C., Royal Oak

48145

Augenzentrum am St Franziskus Hospital Munster, Münster

48149

Universitaetsklinikum Muenster, Münster

49546

Foundation for Vision Research, Grand Rapids

50009

Hosp. Clinico Univ. Lozano Blesa, Zaragoza

Hosp. Univ. Miguel Servet, Zaragoza

53127

Universitaets-Augenklinik Bonn, Bonn

55416

Retina Consultants of Minnesota, Saint Louis Park

60126

Retina Associates, Elmhurst

60439

University Retina, Lemont

60612

University Of Illinois, Chicago

63144

The Retina Institute, St Louis

67063

Klinikum Ludwigshafen, Ludwigshafen am Rhein

72076

Universitaetsklinikum Tuebingen, Tübingen

75231

Retina Foundation of the Southwest, Dallas

Texas Retina Associates, Dallas

75390

UT Southwestern, Dallas

76087

Strategic Clinical Research Group, Willow Park

76104

Texas Retina Associates, Fort Worth

77025

Houston Eye Associates, Houston

77384

Retina Consultants of Texas, The Woodlands

77401

Retina and Vitreous of Texas, PLLC, Bellaire

Retina Consultants of Texas, Bellaire

78215

San Antonio Eye Center, San Antonio

78240

Retina Associates Of South Texas P A, San Antonio

Retina Consultants of Texas, San Antonio

78750

Austin Clinical Research, Austin

79106

Panhandle Eye Group LLP-Southwest Retina Specialists, Amarillo

79606

Retina Research Institute of Texas, Abilene

80138

Azienda Ospedaliera Univ.- Università Degli studi della Campania - Luigi Vanvitelli, Napoli

80228

Colorado Retina - Lakewood Clinic, Lakewood

84107

Retina Associates of Utah P C, Salt Lake City

Rocky Mountain Retina Consultants, Salt Lake City

84132

University of Utah, Salt Lake City

85053

Retinal Research Institute, Phoenix

85704

Retina Associates Southwest PC, Tucson

89502

Sierra Eye Associates, Reno

90095

Jules Stein Eye Institute UCLA, Los Angeles

91107

California Eye Medical Specialists, Pasadena

91436

The Retina Partners, Los Angeles

92064

Retina Consultants San Diego, Poway

92374

Retina Consultants of Southern California, Redlands

92647

Retina Associates Of Southern California, Huntington Beach

92835

Retina Consultants of Orange County, Fullerton

93036

California Retina Consultants, Oxnard

94303

Stanford Health Care, Palo Alto

94598

Bay Area Retina Associates, Walnut Creek

97239

Casey Eye Institute, Portland

97401

Verum Research LLC, Eugene

97477

Cascade Medical Research Institute, LLC, Springfield

99204

Spokane Eye Clinical Research, Spokane

92093 0946

Shiley Eye Institute Jacobs Retina Center, La Jolla

04101

Maine Eye Center, Portland

02114

Ophthalmic Consultants of Boston, Boston

01605

Vitreo Retinal Associates-Worcester, Worcester

08034

Wills Eye/Mid Atlantic Retina, Cherry Hill

27705-4699

Duke University, Durham

T2H 0C8

Calgary Retina Consultants, Calgary

T5H 0X5

Alberta Retina Consultants, Edmonton

K1H 8L6

The Ottawa Hospital Research Institute, Ottawa

K2B 7E9

The Retina Centre of Ottawa, Ottawa

J7H 0E8

Institut De L'oeil Des Laurentides, Boisbriand

530 02

OFTEX Ltd. - EYE CENTER, Pardubice

100 34

Fakultni nemocnice Kralovske Vinohrady, Prague

04103

Universitaetsklinikum Leipzig, Leipzig

00168

Policlinico Universitario Agostino Gemelli, Roma

1105 AZ

Amsterdam University Medical Centers Location Academic Medical Center, Amsterdam

6525 GA

Radboudumc, Nijmegen

85 157

Oculomedica, Bydgoszcz

85 631

Oftalmika, Bydgoszcz

33 100

Uno Med, Tarnów

01 258

Warszawski Szpital Okulistyczny, Warsaw

3000 075

Uls Coimbra - Hosp. Univ. Coimbra, Coimbra

3030-163

Espaco Medico de Coimbra, Coimbra

4200 319

Uls Sao Joao - Hosp. Sao Joao, Porto

08021

Centro de Oftalmologia Barraquer, Barcelona

08022

Centro Medico Teknon S.L., Barcelona

Inst. Cat. de Retina, Barcelona

08025

Hosp. Dos de Maig, Barcelona

08035

Inst. de Microcirugia Ocular, Barcelona

08195

Idc Salud Hosp. Gral. de Catalunya, Sant Cugat del Vallès

171 64

S:t Eriks Ogonsjukhus, Stockholm

06230

Hacettepe University Hospital, Ankara

06490

Baskent University Ankara Hospital, Ankara

06800

Ankara Bilkent Sehir Hastanesi, Ankara

BS1 2LX

Bristol Eye Hospital, Bristol

EC1V 2PD

Moorfields Eye Hospital, London

NW10 7NS

Central Middlesex Hospital, London

W1G 9AX

The Retina Clinic London, London

M13 9WL

Manchester Royal Eye Hospital, Manchester

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

OX3 9DU

Oxford Eye Hospital, Oxford

SO16 6YD

Southampton University Hospital, Southampton

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY