PanACEA - STEP2C -01

BTZ-043 1000mg once daily in arms 4 and 6.

Rifampicin will be dosed in a fixed high-dose (2100 mg for arms 1 and 2) or a weight-banded regular dose (10 mg/kg) in arm 3, 5 and 7.

Isoniazid will be dosed at fixed dose of 300mg in arms 1 and 2, and regular dose of 5 mg/kg in arm 3 and 7.

Pyrazinamide will be dosed in a fixed regular dose in arm 1 (1600 mg), a weight banded high dose in arm 2 (2000/2400 mg) or a weight-banded regular dose (25 mg/kg) in arm 3, 5 and 7.

Moxifloxacin will be dosed at 600 mg orally once daily in arms 1-2.

Alpibectir 45 mg OD plus Ethionamide 500 mg OD combined with rifampicin pyrazinamide and ethambutol at standard weight-banded doses in arm 5.

Ganfeborole 20 mg OD in arm 6

Delpazolid 1200mg OD in arm 6

Pretomanid 20mg OD in arm 6.

Ethambutol 20mg/Kg OD in arm 3, 5 and 7

Ethionamide 500mg OD in arm 5.