NCT05805800View on ClinicalTrials.gov

Olanzapine and 5-HT3 With or Without Dexamethasone to Prevent CINV

PHASE3CompletedINTERVENTIONAL
Enrollment

275

Participants

Timeline

Start Date

April 15, 2023

Primary Completion Date

April 30, 2024

Study Completion Date

May 15, 2024

Conditions
Chemotherapy-induced Nausea and Vomiting
Interventions
DRUG

5HT3RA+Olanzapine

"Using one of the 5-HT3 receptor antagonists within 30 minutes before cisplatin/adriamycin/cyclophosphamide.~On day 1-4, Olanzapine is delivered orally after dinner."

DRUG

5HT3RA+Olanzapine+Dexamethasone

"Using one of the 5-HT3 receptor antagonists within 30 minutes before cisplatin/adriamycin/cyclophosphamide.~On day 1-4, Olanzapine is delivered orally after dinner. On first day, dexamethasone is given orally within 30 minutes before cisplatin/adriamycin/cyclophosphamide administered."

Trial Locations (1)

610041

West China Hospital, Sichuan University, Chengdu

All Listed Sponsors
lead

Xingchen Peng

OTHER