Venetoclax Combined With Homoharringtonine and Cytarabine in Induction for AML

Starting on day 1, venetoclax will be dose escalated to a target dose of 600 mg in the following manner: 100 mg on day 1, 200 mg on day 2 and 400 mg on day 3. The patient then continues to take the 400mg dose for the remainder of the 28 day cycle. Each dose of venetoclax will be self-administered with approximately 240 mL of water within 30 minutes after the completion of a meal, preferably breakfast. The dose should be administered at the same time each day.

On day 1, homoharringtonine 1 mg/m2 IV will be given, and will continue for 5 days.

On day 1, cytarabine 100 mg/m2 IV will be given, and will continue for 5 days.