A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

2,749

Participants

Timeline

Start Date

April 3, 2023

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Type 2 DiabetesObesityOverweight or ObesityOverweightCardiovascular DiseasesChronic Kidney Disease
Interventions
DRUG

Orforglipron

Administered orally once daily

DRUG

Insulin Glargine

Administered SC once daily

Trial Locations (358)

1030

Klinik Landstraße, Vienna

1060

Zentrum für klinische Studien Dr Hanusch Gmbh, Vienna

1061

Buenos Aires Macula S.A, Buenos Aires

1090

Universitaetsklinikum Allgemeines Krankenhaus Wien, Vienna

1130

Klinik Hietzing, Vienna

1407

CEMEDIC, Buenos Aires

1417

Centro Privado de Medicina Familiar / Mindout Research, Buenos Aires

1425

Cardiología Palermo, Buenos Aires

2000

Instituto Médico Catamarca IMEC, Rosario

2152

Centro de Investigaciones Clínicas Baigorria, Granadero Baigorria

4000

Investigaciones Clínicas Tucumán, San Miguel de Tucumán

4021

Konventhospital der Barmherzigen Brüder Linz, Linz

5000

Hospital San Roque, Córdoba

5280

Krankenhaus St. Josef Braunau, Braunau am Inn

5509

Polo de Salud Vistalba, Luján de Cuyo

6800

VIVIT, Feldkirch

8036

Medizinische Universität Graz, Graz

8511

Private Practice - Dr. Evelyn Fliesser-Gorzer, Sankt Stefan ob Stainz

10036

IMA Clinical Research Manhattan, New York

10530

IMA Clinical Research Westchester, Hartsdale

11106

NYC Research INC, Long Island City

11203

SUNY Downstate Health Sciences University, Brooklyn

11527

"General Hospital of Athens G. Gennimatas", Athens

General Hospital of Athens Laiko, Athens

11923

Hanyang University Guri Hospital, Guri-si

12208

Albany Stratton VA Medical Center, Albany

12462

Attikon General University Hospital, Chaïdári

12553

Mid Hudson Medical Research, New Windsor

13057

Velocity Clinical Research, Syracuse, East Syracuse

13187

Diabetespraxis Dr. Braun, Berlin

13620

Seoul National University Bundang Hospital, Seongnam

13905

Meridian Clinical Research, LLC, Binghamton

14004

Hospital Universitario Reina Sofia, Córdoba

14900

Milan Kvapil s.r.o., Diabetologicka ambulance, Prague

15006

CHUAC-Complejo Hospitalario Universitario A Coruña, A Coruña

15009

Heritage Valley Medical Group, Inc., Beaver

15243

Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair, Pittsburgh

15401

Preferred Primary Care Physicians, Uniontown

17074

Capital Area Research - Newport, Newport

17562

Iatriko Paleou Falirou Medical Center, Palaió Fáliro

19114

Clinical Research of Philadelphia, Philadelphia

20070

Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre, Pamukkale

20110

Manassas Clinical Research Center, Manassas

20124

Clínica San Cosme, Aguascalientes

20132

Ospedale San Raffaele, Milan

20230

Centro de Investigación Cardiometabólica de Aguascalientes, Aguascalientes

20852

Endocrine and Metabolic Consultants, Rockville

21100

Dicle Üniversitesi, Diyarbakır

21229

Maryland Cardiovascular Specialists, Baltimore

22500

Centro de Investigacion Cardiovascular y Metabólica, Tijuana

23114

Virginia Research Center, Midlothian

23435

Centricity Research Suffolk Family Medicine, Suffolk

23510

Eastern Virginia Medical School (EVMS) Strelitz Diabetes Research Center, Norfolk

23758

RED-Institut GmbH, Oldenburg

24127

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo

25001

Diacentrum Brandys n.L. s.r.o., Brandýs nad Labem

26426

Wonju Severance Christian Hospital, Wŏnju

Yonsei University-Wonju Severance Christian Hospital, Wŏnju

27408

PharmQuest Life Sciences, LLC, Greensboro

27514

University of North Carolina Medical Center, Chapel Hill

28006

Complejo Hospitalario Ruber Juan Bravo, Madrid

28100

Azienda Ospedaliero Universitaria Maggiore della Carità, Novara

28150

Carolina Research Center, Shelby

28223

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón

28314

Care Access - Fayetteville, Fayetteville

28401

Accellacare - Wilmington - 1917 Tradd Court, Wilmington

28557

Lucas Research, Inc, Morehead City

28625

Accellacare - Piedmont, Statesville

29607

The Research Center of The Upstate, Greenville

29662

Care Access - Mauldin, Mauldin

30046

Balanced Life Health Care Solutions/SKYCRNG, Lawrenceville

30189

North Georgia Clinical Research, Woodstock

30281

Clinical Research Atlanta, Stockbridge

30291

Rophe Adult and Pediatric Medicine/SKYCRNG, Union City

31210

The Jones Center Clinical Research, Macon

31217

Investigacion En Salud Y Metabolismo Sc, Chihuahua City

32132

Velocity Clinical Research, New Smyrna Beach, Edgewater

32204

Northeast Research Institute - Downtown Office, Jacksonville

32714

Orlando Heart & Vascular Institute, Altamonte Springs

32757

Adult Medicine of Lake County, Mt. Dora

32789

Conquest Research, Winter Park

33011

Hospital Universitario Central de Asturias, Oviedo

33012

Indago Research & Health Center, Inc, Hialeah

33014

Panax Clinical Research, Miami Lakes

33144

L&C Professional Medical Research Institute, Miami

33331

Encore Medical Research - Weston, Weston

33343

Mersin University, Mersin

33401

Metabolic Research Institute, Inc., West Palm Beach

33434

Excel Medical Clinical Trials, Boca Raton

33462

JEM Research Institute, Atlantis

33607

Better Life Clinical Research, Tampa

33614

Precision Research Center, Tampa

33625

Care Access - Tampa, Tampa

33805

Clinical Research of Central Florida, Lakeland

33912

Alliance for Multispecialty Research, LLC, Fort Myers

34000

Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia, Durango

34125

Azienda sanitaria universitaria giuliano isontina ASUGI Ospedale Maggiore- Università di Trieste, Trieste

34452

Nature Coast Clinical Research - Inverness, Inverness

34470

Renstar Medical Research, Ocala

34748

Clinical Site Partners Leesburg, Leesburg

34761

West Orange Endocrinology, Ocoee

35124

Cahaba Research - Pelham, Pelham

35415

Diabetologische Schwerpunktpraxis Marck Linn Pickel, Pohlheim

35660

Syed Research Consultants Llc, Sheffield

36037

MVZ im Altstadt-Carree Fulda GmbH, Fulda

36526

Alliance for Multispecialty Research, LLC, Daphne

36608

Alliance for Multispecialty Research, LLC, Mobile

37388

Tennessee Center for Clinical Trials, Tullahoma

37520

Instituto Cardiovascular de León S.C., León

37909

Alliance for Multispecialty Research, LLC, Knoxville

New Phase Research and Development, Knoxville

38030

Erciyes University Medical Faculty, Kayseri

39008

Hospital Universitario Marqués de Valdecilla, Santander

39069

SKY Clinical Research Network Group - Hall, Fayette

39120

SMO.MD GmbH, Magdeburg

39157

SKY Integrative Medical Center/SKYCRNG, Ridgeland

40002

Hospital General de Segovia, Segovia

40213

L-MARC Research Center, Louisville

41003

Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE), Seville

41013

Hospital Universitario Virgen Del Rocio, Seville

41950

Vithas Hospital Sevilla, Seville

42101

Qualmedica Research, Bowling Green

42415

Yeungnam Univeristy Medical Center, Gyeongsan-si

43213

Centricity Research Columbus Ohio Multispecialty, Columbus

43215

Remington-Davis, Inc, Columbus

44033

Ulsan University Hospital, Ulsan

44130

Diseno y Planeacion en Investigacion Medica, Guadalajara

44280

İnönü Üniversitesi Turgut Özal Tıp Merkezi, Malatya

44670

Private Practice - Dr. Francisco Gerardo Padilla, Guadalajara

45355

Praxis am Markt - Dr. Bernd Becker, Essen

46112

Investigators Research Group, Brownsburg

46123

American Health Network of Indiana, LLC - Avon, Avon

46131

American Health Network of Indiana, LLC - Franklin, Franklin

46140

American Health Network of Indiana, LLC - Greenfield, Greenfield

46600

Hospital Universitario de La Ribera, Alzira

47304

American Health Network of Indiana, LLC - Muncie, Muncie

47715

Qualmedica Research, LLC, Evansville

48098

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division, Troy

48126

Revival Research Institute, Dearborn

50265

Iowa Diabetes and Endocrinology Research Center, West Des Moines

50538

Centrul Medical Endocrinologie si Diabet Dr. Paveliu, Bucharest

52242

University of Iowa, Iowa City

53100

Azienda Ospedaliero Universitaria Senese, Siena

53144

Clinical Investigation Specialists, Kenosha

54303

St. Vincent Hospital d/b/a Prevea Health, Green Bay

58104

Lillestol Research, Fargo

59808

Montana Medical Research, Missoula

59901

Logan Health Research, Kalispell

60012

Midwest CRC, Crystal Lake

60077

NorthShore University Health System, Skokie

60523

AMR Clinical, Oak Brook

60640

Great Lakes Clinical Trials - Ravenswood, Chicago

63005

Clinical Research Professionals, Chesterfield

63017

Diabetes and Endocrinology Specialists, Chesterfield

63303

StudyMetrix Research, City of Saint Peters

64060

Cardiolink Clin Trials, Monterrey

65807

Clinvest Research LLC, Springfield

66100

Università degli Studi Gabriele D' Annunzio, Chieti

66606

Cotton O'Neil Diabetes & Endocrinology, Topeka

Cotton O'Neil Mulvane, Topeka

66780

Praxis Dr. Veronika Wenzl-Bauer, Rehlingen

67114

Alliance for Multispecialty Research, LLC, Newton

70119

Alliance for Multispecialty Research, LLC, New Orleans

70433

Louisiana Heart Center - Convington, Covington

70601

Care Access - Lake Charles (Bayou Pines), Lake Charles

72205

KLR Business Group, Inc. dba Arkansas Clinical Research, Little Rock

73160

Tekton Research, Inc, Moore

74136

Central States Research, Tulsa

75020

Cardio Voyage, Denison

Soma Clinical Trials, Denison

75090

Sherman Clinical Research, Sherman

75098

Soma Clinical Trials, Wylie

75126

Care United Research, Forney

75149

Southern Endocrinology Associates, Mesquite

75208

Thyroid, Endocrinology, and Diabetes, Dallas

75230

Velocity Clinical Research, Dallas, Dallas

76000

Centro de Estudios Clínicos de Querétaro (CECLIQ), Querétaro

76132

Diabetes and Thyroid Center of Ft. Worth, Fort Worth

76164

Valley Institute of Research - Fort Worth, Fort Worth

77024

Victorium Clinical Research - Houston, Houston

77040

Juno Research, Houston

77043

Biopharma Informatic, LLC, Houston

77079

Endocrine Ips, Pllc, Houston

77089

Research Physicians Network, LLC, Houston

77375

Northwest Houston Heart Center, Tomball

78229

Audie L Murphy VA Hospital, San Antonio

Clinical Trials of Texas, LLC, San Antonio

78230

VIP Trials, San Antonio

78231

Consano Clinical Research, LLC, Shavano Park

78404

South Texas Clinical Research, Corpus Christi

78503

Biopharma Informatic, LLC, McAllen

78596

Texas Valley Clinical Research, Weslaco

78681

Texas Diabetes & Endocrinology, P.A., Round Rock

78749

Texas Diabetes & Endocrinology, P.A., Austin

79401

MUDr. Tomas Edelsberger, Krnov

80045

Rocky Mountain Regional VA Medical Center, Aurora

University of Colorado Anschutz Medical Campus, Aurora

80100

University of Naples Federico II, Naples

80230

Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C., Culiacán

80909

Legacy Clinical Trials, Colorado Springs

83221

Elite Clinical Trials, Blackfoot

83440

Elite Clinical Trials, Rexburg

83686

Saltzer Health, Nampa

84088

Velocity Clinical Research, Salt Lake City, West Jordan

84107

Wasatch Clinical Research, LLC, Salt Lake City

84120

Kalo Clinical Research, West Valley City

84453

Gemeinschaftpraxis Dr. med. Martin Prohaska und Dr. med. Felix Schulte, Mühldorf

84790

Chrysalis Clinical Research, St. George

85018

Elite Clinical Studies, LLC, Phoenix

85051

Absolute Clinical Research, Phoenix

85206

Aventiv Research, Mesa

85224

The Institute for Liver Health, Chandler

85281

Alliance for Multispecialty Research, LLC, Tempe

85375

Clinical Research Institute of Arizona (CRI) - Sun City West, Sun City West

85381

Arizona Liver Health - Peoria, Peoria

85741

Orange Grove Family Practice, Tucson

87109

IMA Clinical Research, Albuquerque

88100

AOU Renato Dulbecco, Catanzaro

89106

Sierra Clinical Research, Las Vegas

89128

Las Vegas Medical Research, Las Vegas

Palm Research Center Tenaya, Las Vegas

89148

Palm Research Center Sunset, Las Vegas

89440

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, Ciudad Madero

89511

Northern Nevada Endocrinology, Reno

89521

Renown South Meadows Medical Center, Reno

90017

Velocity Clinical Research, Los Angeles, Los Angeles

90720

Pacific Clinical Studies, Los Alamitos

90815

Ark Clinical Research, Long Beach

91303

Hope Clinical Research, Inc., Canoga Park

91325

Valley Clinical Trials, Inc., Northridge

91361

Millennium Clinical Trials, Westlake Village

91606

Velocity Clinical Research, North Hollywood, North Hollywood

91723

Valley Clinical Trials, Inc., Covina

91730

Rancho Cucamonga Clinical Research, Rancho Cucamonga

92025

Neighborhood Healthcare Institute of Health, Escondido

92630

Orange County Research Center, Lake Forest

92704

Velocity Clinical Research, Coastal Heart Medical Group, Santa Ana

92860

Infinity Clinical Research - Norco, Norco

93720

Valley Research, Fresno

94070

LCGK Research, San Carlos

94583

Norcal Endocrinology & Internal Medicine, San Ramon

94598

Diablo Clinical Research, Inc., Walnut Creek

95030

Schwerpunktpraxis für Diabetes Hormone & Stoffwechsel, Hof

97202

Northwest Research Center, Portland

98052

Eastside Research Associates, Redmond

98405

Universal Research Group, Tacoma

99202

MultiCare Rockwood Clinic- Main, Spokane

99817

Gemeinschaftspraxis für Diabetologie, Eisenach

100169

Diabmed Dr. Popescu Alexandrina, Ploieşti

300288

Cabinet Medical Dr.Geru, Timișoara

302020

Eternal Heart Care Center and Research Institute, Jaipur

380006

V.S. General Hospital, Ahmedabad

395002

Nirmal Hospital Pvt Ltd., Surat

400012

King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College, Mumbai

410147

Diabdana, Oradea

410159

Centrul Medical Grandmed, Oradea

411021

Chellaram Diabetes Institute, Pune

440015

Central India Cardiology and Research Institute, Nagpur

440055

Clinica Korall, Satu Mare

500097

Mariodiab Clinic, Brasov

500283

C.M.D.T.A. Neomed, Brasov

540142

Centrul Medical Mediab, Târgu Mureş

560002

Victoria Hospital, Bangalore Medical College And Research Institute, Bangalore

560092

Life Care Hospital and Research Centre, Bangalore

580021

Karnataka Institute of Medical Sciences, Hubli

600154

CMI Dr.Pletea Noemi SRL, Bacau

600274

SC Minimed SRL, Bacau

700547

Centrul Medical Consultmed, Iași

700732

Cardiomed Iași, Iași

753001

S C B Medical College and Hospital, Cuttack

781033

Apollo Excelcare Hospital, Guwahati

800001

Milena Sante, Galați

800291

Diamed Obesity, Galați

29055450

CEDOES, Vitória

06517

CMR of Greater New Haven, LLC, Hamden

01844

ActivMed Practices and Research, Methuen

08816

UniMed Center, East Brunswick

C1061AAS

CIPREC, Buenos Aires

C1120AAC

Centro Médico Viamonte, Buenos Aires

C1128AAF

Mautalen Salud e Investigación, Buenos Aires

C1425AGC

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada, Buenos Aires

C1430CKE

Glenny Corp. S.A., Buenos Aires

C1440AAD

CENUDIAB, Buenos Aires

C1015ABO

Organizacion Medica de Investigacion, CABA

49055-530

Centro de Pesquisa Clinica do Coracao, Acaraju

71625-175

Centro de Pesquisa Clinica do Brasil, Brasília

71681-603

Hospital Brasilia, Brasília

13060-080

Instituto de Pesquisa clinica de Campinas, Campinas

13060-803

Centro de Pesquisa Sao Lucas, Campinas

13092-133

Loema Instituto de Pesquisa Clinica, Campinas

60160-230

Instituto de Estudos e Pesquisas Clinicas do Ceara IEP-CE, Fortaleza

90035-001

Hospital Moinhos de Vento, Porto Alegre

90430-001

Núcleo de Pesquisa Clínica do Rio Grande do Sul, Porto Alegre

20241-180

IBPClin - Instituto Brasil de Pesquisa Clínica, Rio de Janeiro

09080-110

Pesquisare Saude, Santo André

12243-280

ISPEM - Instituto São José dos Campos em Pesquisas Médicas, São José dos Campos

01228-200

CPCLIN, São Paulo

01229-010

NotreDame Intermedica Saude S.A, São Paulo

01236030

BR Trials - Ensaios Clinicos e Consultoria, São Paulo

01409-902

Hospital 9 De Julho, São Paulo

04012-909

Instituto Dante Pazzanese de Cardiology, São Paulo

615 00

EFERTUS healthcare s.r.o., Brno-Židenice

550 01

EDUMED - Broumov, Broumov

381 01

Nemocnice Cesky Krumlov, Český Krumlov

753 01

AIDIN VK s.r.o., Hranice

551 01

EDUMED - Jaroměř, Jaroměř

547 01

EDUMED - Náchod, Náchod

779 00

PreventaMed, Olomouc

702 00

Private Practice - Dr. Miroslav Koliba, Ostrava

530 02

Diahelp s.r.o, Pardubice V

301 00

Dialine - Interni a diabetologicka ambulance, Pilsen

140 00

DiaVize s.r.o., Prague

MEDICON, Prague

MUDr. Michala Pelikanova s.r.o., Prague

150 00

EUC Klinika Praha, Prague

Praglandia s.r.o, Prague

160 00

FLEDIP s.r.o., Prague

Nefromed, Prague

190 14

MUDr. Barbora Diepoltova, Praha 9 - Klanovice

04249

Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut, Leipzig

351 00

General Hospital of Lamia, Lamia

546 35

G. Gennimatas General Hospital of Thessaloniki, Thessaloniki

06132

AO Santa Maria della Misericordia, Perugia

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma

00725

Centro de Endocrinologia y Nutricion, Caguas

00646

Dorado Medical Complex, Dorado

00674

Manati Center for Clinical Research, Manatí

00717

Puerto Rico Medical Research, Ponce

Research and Cardiovascular Corp., Ponce

00917

GCM Medical Group, PSC - Hato Rey Site, San Juan

00918

Mindful Medical Research, San Juan

00921

Mgcendo Llc, San Juan

00694

Wellness clinical Research Vega Baja, Vega Baja

010507

Nicodiab, Bucharest

010627

Geea Medical Easy Diet, Bucharest

011053

Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului, Bucharest

013764

Centrul Medical NutriLife, Bucharest

831 01

Diacrin s.r.o., Bratislava

014 01

Diab - Int, Bytča

04001

Human Care s.r.o., Košice

984 01

IN-DIA, Lučenec

034 91

NEDÚ - Národný endokrinologický a diabetologický ústav n.o., Ľubochňa

901 01

MediVet s.r.o., Malacky

020 01

DIA-MED CENTRUM s.r.o., Púchov

04801

Tatratrial s.r.o., Rožňava

083 01

MEDI-DIA s.r.o., Sabinov

075 01

Areteus s.r.o., Trebišov

917 01

JAL, Trnava

01830

Eulji University Hospital, Daejeon

Nowon Eulji Medical Center, Eulji University, Seoul

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05278

Kyung Hee University Hospital at Gangdong, Seoul

06591

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul

06230

Ankara Universitesi Tip Fakultesi Hastanesi, Ankara

09100

Adnan Menderes University Medical Faculty, Aydin

01250

Baskent University Dr. Turgut Noyan Research and Training Center, Yüreğir

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY