Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

November 8, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Metastatic Colorectal CarcinomaMetastatic Malignant Solid NeoplasmStage IV Colorectal Cancer AJCC v8Unresectable Colorectal CarcinomaUnresectable Malignant Solid Neoplasm
Interventions
DRUG

BET Bromodomain Inhibitor ZEN-3694

Given PO

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

DRUG

Capecitabine

Given PO

PROCEDURE

Computed Tomography

Undergo CT and PET/CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

Trial Locations (22)

10032

SUSPENDED

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

RECRUITING

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

37204

RECRUITING

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

62269

RECRUITING

Memorial Hospital East, Shiloh

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Clinical Research Center, Fairway

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH