60
Participants
Start Date
March 24, 2023
Primary Completion Date
August 31, 2025
Study Completion Date
August 31, 2025
Active 10-Hz TMS to the parietal cortex
The active 10-Hz TMS group will receive 10hz TMS stimulation in the first TMS session, and single pulse TMS in the second TMS session. Participants in the active stimulation group will receive 10-Hz TMS to right parietal cortex. The TMS target will be based on subject specific anatomical MRI images (diffusion imaging). TMS will be delivered using a robotic neuronavigation system (Smartmove, ANT). Stimulation intensity will be standardized at 110% of RMT and adjusted to the skull to cortical surface based on e-field calculations (simnibs). Stimulation will be delivered to the right parietal cortex using an active/placebo figure-8 coil, an magventure TMS device.
Active single pulse TMS to the parietal cortex
The active single pulse TMS group will receive single pulse TMS stimulation in the first and second TMS session. Participants in the active stimulation group will receive single pulse TMS to right parietal cortex. The TMS target will be based on subject specific anatomical MRI images (diffusion imaging). TMS will be delivered using a robotic neuronavigation system (Smartmove, ANT). Stimulation intensity will be standardized at 110% of RMT and adjusted to the skull to cortical surface based on e-field calculations (simnibs). Stimulation will be delivered to the right parietal cortex using an active/placebo figure-8 coil, an magventure TMS device.
Sham 10-Hz TMS to the right parietal cortex
The parameters in the active arms will be as above with the internal randomization of the device internally switching to sham in a blinded fashion.
Sham single-pulse rTMS the rigt parietal cortex
The parameters in the active arms will be as above with the internal randomization of the device internally switching to sham in a blinded fashion.
RECRUITING
Rutgers University - Newark, Newark
Rutgers, The State University of New Jersey
OTHER