NCT05800405View on ClinicalTrials.gov

Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

July 20, 2023

Primary Completion Date

October 20, 2025

Study Completion Date

October 20, 2025

Conditions
Recurrent Diffuse Large B-Cell LymphomaRefractory Diffuse Large B-Cell Lymphoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

BIOLOGICAL

Chimeric Antigen Receptor T-Cell Therapy

Receive CAR-T per standard of care

PROCEDURE

Computed Tomography

Undergo PET/CT

RADIATION

External Beam Radiation Therapy

Undergo radiation therapy

PROCEDURE

Leukapheresis

Receive leukapheresis

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

Trial Locations (1)

91010

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER