Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

268

Participants

Timeline

Start Date

July 17, 2023

Primary Completion Date

August 31, 2025

Study Completion Date

July 31, 2027

Conditions
Endometrial Cancer
Interventions
DRUG

Navtemadlin

Navtemadlin is an experimental MDM2 anticancer drug taken by mouth

DRUG

Navtemadlin Placebo

Navtemadlin placebo is a placebo that is the same in appearance to navtemadlin drug taken by mouth

Trial Locations (83)

1000

RECRUITING

Institute of Oncology Ljubljana, Ljubljana

1090

RECRUITING

Medizinische Universität Wien, Vienna

2000

RECRUITING

University Clinical Center Maribor, Maribor

4032

RECRUITING

University of Debrecen Clinical Center, Debrecen

4604

RECRUITING

Southern Hospital Sorlandet, Kristiansand

6000

RECRUITING

LTD High Technology hospital Medcenter, Batumi

6020

RECRUITING

Medizinische Universität Innsbruck, Innsbruck

8036

RECRUITING

University Hospital Graz, Department of Gynecology and Obstetrics, Graz

9038

RECRUITING

Sykehusapotek Nord Tromsø, Tromsø

11407

RECRUITING

H.G.U. Jerez de la Frontera, Jerez de la Frontera

11795

RECRUITING

Good Samaritan Hospital Medical Center, West Islip

15006

RECRUITING

CHUAC (Hospital de Coruña), A Coruña

15706

RECRUITING

HCU Santiago de Compostela, Santiago de Compostela

16132

RECRUITING

Ospedale Policlinico San Martino, Genoa

20162

RECRUITING

Osp. Niguarda, Milan

20520

RECRUITING

Turku University Hospital, Turku

20904

RECRUITING

Maryland Oncology Hematology, P.A., Silver Spring

21110

RECRUITING

Ospedale Filippo Del Ponte, Varese

23007

RECRUITING

Hospital Universitario de Jaen, Jaén

23900

RECRUITING

ASST di Lecco-Ospedale Alessandro Manzoni, Lecco

24008

RECRUITING

Hospital de Leon, León

28374

RECRUITING

FirstHealth Carolinas, Pinehurst

29121

RECRUITING

Ospedale Guglielmo da Saliceto, Piacenza

30342

RECRUITING

Northside Hospital, Atlanta

31405

RECRUITING

St. Joseph, Savannah

35016

RECRUITING

Hospital U Insular de GC, Las Palmas

41014

RECRUITING

Hospital Universitario de Valme, Seville

43126

RECRUITING

University Hospital of Parma, Parma

43214

RECRUITING

OhioHealth Institute, Columbus

46202

RECRUITING

Indiana University, Indianapolis

46845

RECRUITING

Parkview Research Center, Fort Wayne

47014

RECRUITING

"IRCCS Istituto Romangolo per lo Studio dei Tumori Dino Amadori", Forlì

47923

RECRUITING

"Azienda Unità Sanitaria Locale della Romagna - Hospital Infermi of Rimini Oncology Department", Rimini

48121

RECRUITING

Ospedale Santa Maria delle Croci, Ravenna

48960

RECRUITING

Hospital Galdakao-Usansolo, Galdakao

50406

RECRUITING

Tartu University Hospital, Tartu

55100

RECRUITING

Ospedale San Luca, Lucca

55404

RECRUITING

Minnesota Oncology Hematology, P.A., Minneapolis

59100

RECRUITING

Ospedale di Prato S. Stefano, Prato

60521

RECRUITING

Dr. Sudarshan K. Sharma, Ltd., Hinsdale

63108

RECRUITING

Washington University School of Medicine, St Louis

70200

RECRUITING

Kuopio University Hospital, Kuopio

74146

RECRUITING

Oklahoma Cancer Specialists and Research Institute, Tulsa

76104

RECRUITING

Texas Oncology-Fort Worth Cancer Center, Fort Worth

78130

RECRUITING

Texas Oncology-San Antonio Medical Center, San Antonio

78745

RECRUITING

Texas Oncology-Austin Central, Austin

89106

RECRUITING

Women's Cancer Center of Nevada, Las Vegas

94589

RECRUITING

Kaiser Permanente Center, Vallejo

95126

RECRUITING

A.O. Cannizzaro, Catania

97227

RECRUITING

Northwest Cancer Specialists, Portland

97401

RECRUITING

Oncology Associates of Oregon, Eugene

110283

RECRUITING

Gral Medical S.R.L. - Oncofort Hospital, Piteşti

200094

RECRUITING

Onco Clinic Consult S.A., Craiova

200542

RECRUITING

"Oncology Center Sf. Nectarie", Craiova

300166

RECRUITING

Oncocenter, Oncology Clinic SRL, Timișoara

300239

RECRUITING

SC Oncomed SRL, Timișoara

905900

RECRUITING

Ovidius Clinical Hospital SRL, Constanța

6423906

RECRUITING

Sourasky Medical Center, Tel Aviv

9103102

RECRUITING

Shaare Zedek Medical Center, Jerusalem

T6G 1Z2

RECRUITING

Cross Cancer Institute, Edmonton

H2X 3E4

RECRUITING

CHUM - University of Montreal Hospital Centre, Montreal

DK-5000

RECRUITING

Odense University Hospital, Odense

0102

RECRUITING

American Hospital Network LLC, Tbilisi

0186

RECRUITING

Caucasus Medical Centre, Tbilisi

H-1122

RECRUITING

National Institute of Oncology, Budapest

Rambam Medical Center

RECRUITING

Rambam Medical Center, Haifa

00161

RECRUITING

Policlinico Umberto, Rome

LT-45434

RECRUITING

Health Sciences Kaunas Clinics, Kaunas

LT-08660

RECRUITING

Nation Cancer Institute of Lithuania, Vilnius, Vilnius

0379

RECRUITING

Oslo University Hospital HF, Oslo

15-027

RECRUITING

Białostockie Centrum Onkologii, Bialystok

80-210

RECRUITING

Szpitale Pomorskie, Gdansk

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

44-102

RECRUITING

NIO-PIB Oddzial w Gliwicach, Gliwice

31-115

RECRUITING

Centrum Badań klinicznych Jagiellońskie Centrum Innowacji, Krakow

10-228

RECRUITING

Siedleckie Centrum Onkologii, Olsztyn

60-569

RECRUITING

Uniwersytecki Szpital, Poznan

02-781

RECRUITING

NIO-PIB Klinika Gine-Onk, Warsaw

53-413

RECRUITING

Lower Silesian Oncology, Pulmonology and Hematology Center, Department of Oncological Gynecology, Wroclaw

012244

RECRUITING

Bucharest CF2 Hospital, Bucharest

08003

RECRUITING

Hospital del Mar, Barcelona

581 85

RECRUITING

Linkoping University Hospital, Linköping

SE-171 76

RECRUITING

Karolinska University Hospital, Stockholm

Sponsors
All Listed Sponsors
collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

GOG Foundation

NETWORK

lead

Kartos Therapeutics, Inc.

INDUSTRY

NCT05797831 - Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer | Biotech Hunter | Biotech Hunter